DNA, Mitochondrial

Known as: DNA, Mitochondrial [Chemical/Ingredient], mtDNA, Mitochondrial DNA 
Typically small, circular, intronless, and maternally inherited, mitochondrial DNA (mtDNA) is the multicopy deoxyribonucleic acid genome of… (More)
National Institutes of Health

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29 relations
Clinical Data Interchange Standards Consortium TerminologyExtrachromosomal InheritanceGenes, MitochondrialIn Blood
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Broader (3)

DNAMitochondrial matrixextrachromosomal DNA

Papers overview

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Review
2017
Review
2017
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
As regulators of bioenergetics in the cell and the primary source of endogenous reactive oxygen species (ROS), dysfunctional… (More)
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Highly Cited
2012
Highly Cited
2012
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling… (More)
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Highly Cited
2011
Highly Cited
2011
Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release
Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. Here we demonstrate that… (More)
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Highly Cited
2009
Highly Cited
2009
Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation.
Human mitochondrial DNA is widely used as tool in many fields including evolutionary anthropology and population history, medical… (More)
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Highly Cited
2005
Highly Cited
2005
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to… (More)
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Highly Cited
2004
Highly Cited
2004
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in a variety of tissues during ageing in humans, monkeys… (More)
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Highly Cited
1993
Highly Cited
1993
Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.
Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees… (More)
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Highly Cited
1989
Highly Cited
1989
Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.
With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify… (More)
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Highly Cited
1988
Highly Cited
1988
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of… (More)
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Highly Cited
1985
Highly Cited
1985
Dating of the human-ape splitting by a molecular clock of mitochondrial DNA
A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is… (More)
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