DLC1 gene

Known as: RHO GTPase-ACTIVATING PROTEIN 7, HP, p122-RhoGAP 
This gene plays a role in cytoskeletal organization and regulation of cell growth.
National Institutes of Health

Papers overview

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2011
2011
The critical 8p22 tumor suppressor deleted in liver cancer 1 (DLC1) is frequently inactivated by aberrant CpG methylation and/or… (More)
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Highly Cited
2008
Highly Cited
2008
Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region… (More)
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Highly Cited
2007
Highly Cited
2007
Identification of tumor suppressor genes (TSG) silenced by methylation uncovers mechanisms of tumorigenesis and identifies new… (More)
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Highly Cited
2007
Highly Cited
2007
The three deleted in liver cancer genes (DLC1-3) encode Rho-GTPase-activating proteins (RhoGAPs) whose expression is frequently… (More)
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2007
2007
Epigenetic mechanisms involving DNA methylation and chromatin remodeling are important in silencing tumor suppressor genes (TSG… (More)
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Highly Cited
2004
Highly Cited
2004
The deleted in liver cancer (DLC-1) gene at chromosome 8p21–22 is altered mainly by genomic deletion or aberrant promoter… (More)
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Highly Cited
2003
Highly Cited
2003
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers in the world. However, the underlying molecular mechanisms… (More)
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Highly Cited
2003
Highly Cited
2003
DLC-1 (deleted in liver cancer) gene is frequently deleted in hepatocellular carcinoma. However, little is known about the… (More)
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Highly Cited
1999
Highly Cited
1999
The short arm of chromosome 3 is thought to contain multiple tumor suppressor genes, because one copy of this chromosomal arm… (More)
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Highly Cited
1998
Highly Cited
1998
The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here… (More)
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