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Intertumoral Heterogeneity within Medulloblastoma Subgroups.
TLDR
Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. Expand
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
TLDR
Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct, and co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H 3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H2.1K 27M are identified. Expand
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis.
TLDR
Three molecular subgroups of CNS PNETs that were distinguished by primitive neural, oligoneural, and mesenchymal lineage gene-expression signatures with differential expression of cell-lineage markers LIN28 and OLIG2 are identified. Expand
Activation of GPR30 inhibits growth of prostate cancer cells via sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G2 cell-cycle arrest
TLDR
This study dissected the mechanism underlying G-1-induced inhibition of PC-3 cell growth, which was mediated through GPR30, followed by sustained activation of Erk1/2 and a c-jun/c-fos-dependent upregulation of p21, resulting in the arrest ofPC-3 growth at the G2 phase. Expand
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.
TLDR
It is concluded that phosphorylation of eIF2alpha is associated with the degeneration of neurons in AD. Expand
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease
TLDR
It is concluded that phosphorylation of eIF2alpha is associated with the degeneration of neurons in AD. Expand
A frequent activated smoothened mutation in sporadic basal cell carcinomas
TLDR
The finding of a high smoothened mutation rate, together with high frequent patched gene mutations reported recently, indicates that activation of the hedgehog signal transduction pathway is the most common and early event in the development of sporadic BCCs. Expand
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.
TLDR
BRAF V600E PLGG constitutes a distinct entity with poor prognosis when treated with current adjuvant therapy, and additional multivariable clinical and molecular stratification revealed that the extent of resection and CDKN2A deletion contributed independently to poor outcome in BRAF V 600E PL GG. Expand
miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.
TLDR
This study demonstrates that miR-124 deregulation is common in medulloblastomas, and restoration of its function inhibits cell proliferation, suggesting that mi R-124 may act as a growth suppressor and raise the possibility that the miR -124/SLC16A1 pathway may represent a novel therapeutic target for treatment of malignant medullOBlastomas. Expand
Clinical significance of vasculogenic mimicry in human gliomas
TLDR
The results suggest that VM channels in gliomas correlate with increasing malignancy and higher aggressiveness, and may provide a complementation to the tumor’s blood supply, especially in less vascularized regions, which may aid in the identification of glioma patients with a poorer prognosis. Expand
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