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DLC1 protein, human

Known as: Rho GTPase-Activating Protein 7, Deleted in Liver Cancer 1 Protein, START Domain-Containing Protein 12 
Rho GTPase-activating protein 7 (1528 aa, ~171 kDa) is encoded by the human DLC1 gene. This protein is involved in the mediation of both signal… 
National Institutes of Health

Related topics

Related topics

14 relations
Breast CarcinomaCarcinoma of lungCell AdhesionColorectal Carcinoma

Broader (2)

GTPase-Activating ProteinsTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The Role of Tumor Suppressor DLC-1: Far From Clear.
BACKGROUND Deleted in liver cancer 1 (DLC-1) In human was originally isolated from rats brain and was often found to be deleted… 
2015
2015
Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
DLC1 has been shown to be downregulated or absent in hepatocellular carcinoma (HCC) and is associated with tumorigenesis and… 
2013
2013
Aberrant deleted in liver cancer‐1 expression is associated with tumor metastasis and poor prognosis in urothelial carcinoma
This study explored the potential role of deleted in liver cancer‐1 (DLC‐1) as a prognostic indicator of cancer metastasis and… 
2010
2010
Crossveinless‐c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down‐regulating Rho1 activity
Diverse neuronal subtypes develop distinctive morphologies of dendritic arbors that receive synaptic or sensory inputs. Dendritic… 
2009
2009
Restoration of DLC1 gene inhibits proliferation and migration of human colon cancer HT29 cells.
DLC1 (deleted in liver cancer-1) is a new candidate tumor suppressor gene, which is inactive in various types of human cancers… 
2008
2008
Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line.
DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the… 
2005
2005
Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor.
2005
2005
[Relationship between DLC-1 expressions and metastasis in hepatocellular carcinoma].
OBJECTIVES To study the relationship between the expression level of DLC-1 mRNA (located in 8p) and the invasion/metastasis of… 
2004
2004
Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers.
Absence or low expression of DLC-1, a tumor suppressor gene, in breast cancers has been shown recently. LOH of 8p12-p22, on which… 
2002
2002
Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7).
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