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A brief overview is provided that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied thanIntegrins in other organisms. Expand
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site
The VCAM-1/VLA-4 ligand-receptor pair may play a major role in the recruitment of mononuclear leukocytes to inflammatory sites in vivo. Expand
Fibulin-5/DANCE is essential for elastogenesis in vivo
It is reported that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization and may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibre in the skin, lung and vasculature. Expand
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
Targeting of the statin-binding site of LFA-1 could be used to treat diseases such as psoriasis, rheumatoid arthritis, ischemia/reperfusion injury and transplant rejection. Expand
Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355425) of the Common 1 Chain (*)
- A. Luque, M. Gómez, W. Puzon, Y. Takada, F. Sánchez-Madrid, C. Cabañas
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 10 May 1996
Interestingly, binding of HUTS mAbs to partially activated VLA integrins results in maximal activation of these adhesion receptors and enhancement of cell adhesion to β1 integrin ligands collagen, laminin, and fibronectin. Expand
Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
It is suggested that the substitution at residue 11 generates an amphiphilic alpha-helix with characteristics similar to recognized mitochondrial targeting sequences, the full functional expression of which is dependent upon coexpression of the substituted amino acid at residue 170, which may induce defective peroxisomal import. Expand
Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies.
A small region of beta 1 subunit (residues 207-218) is identified that is critical for the binding of both activating and inhibiting monoclonal antibodies against human beta 1 using interspecies chimeric beta 1 and site-directed mutagenesis. Expand
Inhibition of tissue factor signaling suppresses tumor growth.
The results show that tumor cell TF-PAR2 signaling is crucial for tumor growth and suggest that anti-TF strategies can be applied in cancer therapy with minor impairment of TF-dependent hemostatic pathways. Expand
Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1
Oocytes and α9β1 have similar binding specificities for ADAMs and that α9 β1, or a receptor with similar specificity, may be involved in sperm-egg interaction during fertilization. Expand
Characterization of the cell surface heterodimer VLA-4 and related peptides.
- M. Hemler, C. Huang, Y. Takada, L. Schwarz, J. Strominger, M. Clabby
- Medicine, Biology
- The Journal of biological chemistry
- 25 August 1987
Studies of dissociated subunits showed that B-5G10 recognizes an epitope on the Mr 150,000 alpha 4 subunit of VLA-4, whereas the beta subunit is immunologically identical to the Mr 130,000 beta sub unit common to all VLA heterodimers. Expand