DICER1 protein, human

Known as: Endoribonuclease Dicer, Helicase with RNase Motif, K12H4.8-Like 
Endoribonuclease Dicer (1922 aa, ~219 kDa) is encoded by the human DICER1 gene. This protein plays a role in both pri-miRNA processing and RNA… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing… (More)
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Highly Cited
2012
Highly Cited
2012
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA… (More)
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Highly Cited
2010
Highly Cited
2010
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic… (More)
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Highly Cited
2009
Highly Cited
2009
While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely… (More)
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Highly Cited
2009
Highly Cited
2009
Pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that is often part of an inherited cancer syndrome. PPBs consist of… (More)
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Highly Cited
2009
Highly Cited
2009
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting messenger RNA (mRNA) transcripts. Recently… (More)
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Highly Cited
2007
Highly Cited
2007
MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants and animals, often act post-transcriptionally to… (More)
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Highly Cited
2007
Highly Cited
2007
Dicer is a key enzyme involved in the maturation of microRNAS (miRNAs). miRNAs have been shown to be regulators of gene… (More)
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) and trans-acting siRNAs (ta-siRNAs) in plants form through distinct pathways, although they function as… (More)
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Highly Cited
2004
Highly Cited
2004
Micro-RNAs (miRNAs) are small, noncoding RNAs of 18-25 nt in length that negatively regulate their complementary mRNAs at the… (More)
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