RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells.

@article{KawaseKoga2010RNAaseIIIED,
  title={RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells.},
  author={Yoko Kawase-Koga and Roger Wee Chuang Low and Gaizka Otaegi and Andrew C. Pollock and Haiteng Deng and Frank Eisenhaber and Sebastian Maurer-Stroh and Tao Sun},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 4},
  pages={586-94}
}
An important function of the RNAase-III enzyme Dicer is to process microRNA precursors into ~22-nucleotide non-coding small RNAs. But little is known about the role of Dicer in mammalian brain formation and neural stem cell (NSC) development. Here we show that Dicer plays a crucial role in controlling mouse cortical NSC development. We found that Dicer function is essential for expanding cortical neural progenitors and NSCs. We have identified a population of Dicer-deficient NSCs that can self… CONTINUE READING

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