Genetic Variations in Key MicroRNA Processing Genes and Risk of Head and Neck Cancer: A Case-Control Study in Chinese Population

@inproceedings{Ma2012GeneticVI,
  title={Genetic Variations in Key MicroRNA Processing Genes and Risk of Head and Neck Cancer: A Case-Control Study in Chinese Population},
  author={Hongxia Ma and Hua Yuan and Zhiyao Yuan and Chenjie Yu and Ran Wang and Yue Jiang and Zhibin Hu and Hongbing Shen and Ning Chen},
  booktitle={PloS one},
  year={2012}
}
MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis. Genetic variations in miRNA processing genes and miRNA binding sites may affect the biogenesis of miRNA and the miRNA-mRNA interactions, hence promoting tumorigenesis. In the present study, we hypothesized that potentially functional polymorphisms in miRNA processing genes may contribute to head and neck cancer (HNC) susceptibility. To test this hypothesis, we genotyped three SNPs at miRNA binding sites of miRNA processing… CONTINUE READING
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