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DFFB protein, human

Known as: Caspase-Activated Nuclease, DFF-40, Caspase-Activated DNase 
DNA fragmentation factor subunit beta (338 aa, ~39 kDa) is encoded by the human DFFB gene. This protein is involved in the modulation of DNA… 
National Institutes of Health

Related topics

Related topics

16 relations
ApoptosisApoptosis PromoterCaspase Cascade PathwayCell Nucleus

Broader (1)

Deoxyribonucleases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Dz13 induces a cytotoxic stress response with upregulation of E2F1 in tumor cells metastasizing to or from bone.
The oligonucleotide Dz13 is a DNA enzyme (deoxyribozyme) that cleaves c-Jun mRNA. It has efficacious effects against tumors… 
2009
2009
Facial granulomatous nodules during etanercept treatment for psoriasis
affecting polymorphonuclear cell–endothelial cell adhesion via the modification of CD receptors, and thus downregulating the… 
Review
2006
Review
2006
Unique features of the apoptotic endonuclease DFF40/CAD relative to micrococcal nuclease as a structural probe for chromatin.
The gold standard for studies of nucleosomal chromatin structure for the past 30 years has been the enzyme micrococcal nuclease… 
Highly Cited
2005
Highly Cited
2005
The Contribution of Apoptosis-inducing Factor, Caspase-activated DNase, and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis*
We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the… 
2002
2002
Induction of Caspase-Activated Deoxyribonuclease Activity after Focal Cerebral Ischemia and Reperfusion
Deoxyribonucleic acid fragmentation at nucleosomal junctions is a hallmark of neuronal apoptosis in ischemic brain injury, for… 
2002
2002
Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the hydropic cochlea of guinea pigs – second report
Abstract Apoptosis was induced in the cochlea by the injection of keyhole limpet hemocyanin (KLH) into the endolymphatic sac of… 
Highly Cited
2001
Highly Cited
2001
The Absence of Oligonucleosomal DNA Fragmentation during Apoptosis of IMR-5 Neuroblastoma Cells
Caspase-activated DNase is responsible for the oligonucleosomal DNA degradation during apoptosis. DNA degradation is thought to… 
2001
2001
Induction of apoptotic pathway in the vestibule of cisplatin (CDDP)-treated guinea pigs.
BACKGROUND During the process of apoptosis, double-stranded DNA is broken into single-stranded DNA by the action of caspases and… 
Highly Cited
1999
Highly Cited
1999
Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells.
1999
1999
Letter to the Editor
Fragmentation of genomic DNA is an evolutionary conserved event associated with the execution of apoptosis. The DNA fragmentation… 
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