FAQ

Deoxyribonucleases

Known as: Deoxyribonuclease, DNase, Deoxyribonucleases [Chemical/Ingredient] 
Enzymes that catalyze the hydrolytic cleavage of phosphodiester bond linkages in the DNA backbone. Deoxyribonucleases belong to a larger family of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1943-2018
05010015019432017

Related topics

Related topics

32 relations

Narrower (17)

Acid DNaseAlkaline DNaseDFFB protein, humanDeoxyribonuclease I
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Deoxyribonucleases / PlasminEnzyme GeneEsterase GeneHydrolase
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Broader (1)

phosphoric diester hydrolase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Deoxyribonucleases
physiological aspects
Hydrolase
phosphoric diester hydrolase
In Blood
Deoxyribonuclease I

Papers overview

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Highly Cited
2014
Highly Cited
2014
MutationTaster2: mutation prediction for the deep-sequencing age
To the Editor: The majority of the gene variants discovered by nextgeneration sequencing (NGS) projects are either intronic or… (More)
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Highly Cited
2011
Highly Cited
2011
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
Sequence-specific nucleases represent valuable tools for precision genome engineering. Traditionally, zinc-finger nucleases (ZFNs… (More)
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Highly Cited
2011
Highly Cited
2011
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part… (More)
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Highly Cited
2004
Highly Cited
2004
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
BACKGROUND & AIMS We tested whether the attenuation of experimental colitis by live probiotic bacteria is due to their… (More)
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Highly Cited
2000
Highly Cited
2000
A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein.
Many bacterial pathogens encode a multisubunit toxin, termed cytolethal distending toxin (CDT), that induces cell cycle arrest… (More)
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Highly Cited
1998
Highly Cited
1998
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
The homeostasis of animals is regulated not only by the growth and differentiation of cells, but also by cell death through a… (More)
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Highly Cited
1990
Highly Cited
1990
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.
We have isolated a cDNA clone, PU.1, that codes for a new tissue-specific DNA binding protein. Analysis of the binding site by… (More)
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Highly Cited
1987
Highly Cited
1987
Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
We have constructed a "minilocus" that contains the 5' and 3' flanking regions of the human beta-globin locus and the beta-globin… (More)
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Highly Cited
1987
Highly Cited
1987
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.
The enhancer-binding protein AP-1 has been purified to greater than 95% homogeneity from HeLa cells by sequence-specific DNA… (More)
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Highly Cited
1978
Highly Cited
1978
DNAse footprinting: a simple method for the detection of protein-DNA binding specificity.
A method for studying the sequence-specific binding of proteins to DBA is described. The technique is a simple conjoining of the… (More)
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