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DDIT4 gene

Known as: HIF-1 responsive RTP801, DNA DAMAGE-INDUCIBLE TRANSCRIPT 4, REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1 
This gene is involved in responses to cellular energy levels and cellular stress.
National Institutes of Health

Related topics

Related topics

4 relations
ApoptosisDDIT3 geneDDIT4 wt AlleleDNA Damage-Inducible Transcript 4 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
ZY0511, a novel, potent and selective LSD1 inhibitor, exhibits anticancer activity against solid tumors via the DDIT4/mTOR pathway.
2018
2018
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition
Knowledge about host factors supporting or restricting virus replication is required for a deeper understanding of virus-cell… 
2017
2017
Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
2017
2017
Study on the molecular mechanism of Rac3 on regulating autophagy in human lung cancer cells.
PURPOSE Rac3 plays an important role in regulating tumorigenesis. Autophagy plays a vital role in tumorigenesis and tumor… 
2015
2015
Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.
Sepsis-induced skeletal muscle atrophy and weakness are due in part to decreased mTORC1-mediated protein synthesis and increased… 
Highly Cited
2013
Highly Cited
2013
DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination
Signals that promote myelination must be tightly modulated to adjust myelin thickness to the axonal diameter. In the peripheral… 
2012
2012
The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/β-catenin Activity in Zebrafish
REDD1/redd1 is a stress-response gene that is induced under various stressful conditions such as hypoxia, DNA damage, and energy… 
2011
2011
Neural Stem Cells Modified by a Hypoxia-Inducible VEGF Gene Expression System Improve Cell Viability under Hypoxic Conditions and Spinal Cord Injury
Study Design. An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation of… 
2010
2010
Structural Analysis and Functional Implications of the Negative mTORC 1 Regulator REDD 1 † , ‡
REDD1 is a conserved stress-response protein that regulates mTORC1, a critical regulator of cell growth and proliferation that is… 
2002
2002
Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast.
In the budding yeast Saccharomyces cerevisiae, the preservation of the mating competent haploid (a or alpha) and the mating… 
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