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DAXX gene

Known as: death-domain associated protein, DAXX, DEATH-ASSOCIATED PROTEIN 6 
This gene plays a role in signal transduction, regulation of transcription and enhancement of apoptosis.
National Institutes of Health

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ApoptosisDAXX protein, humanSignal TransductionTranscriptional Regulation

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DAXX wt Allele

Papers overview

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Highly Cited
2017
Highly Cited
2017
ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
The commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX, DAXX, and MEN1. We genotyped 64 PanNETs and… 
Highly Cited
2012
Highly Cited
2012
Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors
Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare malignant neoplasms with a poor prognosis. The… 
Highly Cited
2012
Highly Cited
2012
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
Approximately 45% of sporadic well-differentiated pancreatic neuroendocrine tumors harbor mutations in either ATRX (alpha… 
Highly Cited
2008
Highly Cited
2008
Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
The apoptosis-modulating protein Daxx functions as a transcriptional repressor that binds to and suppresses the activity of… 
Highly Cited
2003
Highly Cited
2003
RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX
The function of DAXX, a highly conserved mammalian gene, has remained controversial; this is due, in part, to its identification… 
Highly Cited
2002
Highly Cited
2002
Essential Role of the 58-kDa Microspherule Protein in the Modulation of Daxx-dependent Transcriptional Repression as Revealed by Nucleolar Sequestration*
Daxx has been reported to mediate the Fas/JNK-dependent signals in the cytoplasm. However, several lines of evidence have… 
Highly Cited
2002
Highly Cited
2002
Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.
Hantaviruses cause two severe diseases, haemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in… 
Highly Cited
2002
Highly Cited
2002
The Interaction of Pax5 (BSAP) with Daxx Can Result in Transcriptional Activation in B Cells*
Pax5 (BSAP) is essential for B cell development and acts both as a transcriptional activator and a repressor. Using a yeast two… 
Highly Cited
2000
Highly Cited
2000
Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis
The promyelocytic leukemia protein (PML) gene of acute promyelocytic leukemia (APL) encodes a cell growth and tumor suppressor… 
Highly Cited
1999
Highly Cited
1999
Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.
The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role… 
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