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Cystine-Knot Miniproteins

Known as: Knottins, Cystine Knot Miniproteins, Knottin 
A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The… Expand
National Institutes of Health

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Related topics

8 relations
In BloodProcess of secretionagonistsantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Bio-inspired design and potential biomedical applications of a novel class of high-affinity peptides.
Antibodies have been widely used in a range of biopharmaceutical and biomedical applications due to their intrinsic high affinity… Expand
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Highly Cited
2010
Highly Cited
2010
Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides
Targeted contrast-enhanced ultrasound imaging is increasingly being recognized as a powerful imaging tool for the detection and… Expand
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Highly Cited
2010
Highly Cited
2010
Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta.
Here we report the design, chemical and recombinant synthesis, and functional properties of a series of novel inhibitors of human… Expand
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Highly Cited
2009
Highly Cited
2009
Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.
There is a critical need for compounds that target cell surface integrin receptors for applications in cancer therapy and… Expand
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Review
2009
Review
2009
Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins.
  • Harald Kolmar
  • Current opinion in pharmacology
  • 2009
    • Corpus ID: 5253009
Owing to their outstanding inherent thermal stability and proteolytic resistance, as well as their small size of only around 30… Expand
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Highly Cited
2009
Highly Cited
2009
Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra*
Hydramacin-1 is a novel antimicrobial protein recently discovered during investigations of the epithelial defense of the ancient… Expand
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Highly Cited
2008
Highly Cited
2008
KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
The KNOTTIN database provides standardized information on the small disulfide-rich proteins with a knotted topology called… Expand
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Highly Cited
2005
Highly Cited
2005
Diversity of wheat anti-microbial peptides
From seeds of Triticum kiharae Dorof. et Migusch., 24 novel anti-microbial peptides were isolated and characterized by a… Expand
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Highly Cited
2001
Highly Cited
2001
Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins.
The "knottin" fold is a stable cysteine-rich scaffold, in which one disulfide crosses the macrocycle made by two other disulfides… Expand
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Review
1998
Review
1998
Plant defense peptides.
Eight families of antimicrobial peptides, ranging in size from 2 to 9 kD, have been identified in plants. These are thionins… Expand
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