Cystine-Knot Miniproteins

Known as: Knottins, Cystine Knot Miniproteins, Knottin 
A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
051019902017

Papers overview

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Review
2016
Review
2016
Peptides with the cystine-knot architecture, often termed knottins, are promising scaffolds for biomolecular engineering. These… (More)
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2011
2011
BACKGROUND AND PURPOSE Cystine-knot miniproteins are characterized by a similar molecular structure. Some cystine-knot… (More)
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2010
2010
Here we report the design, chemical and recombinant synthesis, and functional properties of a series of novel inhibitors of human… (More)
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Highly Cited
2009
Highly Cited
2009
There is a critical need for molecular imaging agents to detect cell surface integrin receptors that are present in human cancers… (More)
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2009
2009
Knottins are small constrained polypeptides that share a common disulfide-bonded framework and a triple-stranded beta-sheet fold… (More)
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2009
2009
There is a critical need for compounds that target cell surface integrin receptors for applications in cancer therapy and… (More)
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2009
2009
Cystine-knot miniproteins (knottins) are promising molecular scaffolds for protein engineering applications. Members of the… (More)
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Highly Cited
2008
Highly Cited
2008
The KNOTTIN database provides standardized information on the small disulfide-rich proteins with a knotted topology called… (More)
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2007
2007
Thrombopoietin is the primary regulator of platelet production. We exploited two naturally occurring miniproteins of the… (More)
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1998
1998
Knottins are a group of small, disulphide-bonded proteins that bind with high specificity to their target molecules. These… (More)
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