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Cystine-Knot Miniproteins

Known as: Knottins, Cystine Knot Miniproteins, Knottin 
A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
051019902017

Related topics

Related topics

8 relations
In BloodProcess of secretionagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cystine-Knot Miniproteins
physiological aspects
In Blood
chemical synthesis
standards characteristics
Process of secretion

Papers overview

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Review
2016
Review
2016
Synthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.
Peptides with the cystine-knot architecture, often termed knottins, are promising scaffolds for biomolecular engineering. These… (More)
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2011
2011
Anti-angiogenic effects of two cystine-knot miniproteins from tomato fruit.
BACKGROUND AND PURPOSE Cystine-knot miniproteins are characterized by a similar molecular structure. Some cystine-knot… (More)
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2010
2010
Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta.
Here we report the design, chemical and recombinant synthesis, and functional properties of a series of novel inhibitors of human… (More)
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Highly Cited
2009
Highly Cited
2009
Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects.
There is a critical need for molecular imaging agents to detect cell surface integrin receptors that are present in human cancers… (More)
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2009
2009
An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.
Knottins are small constrained polypeptides that share a common disulfide-bonded framework and a triple-stranded beta-sheet fold… (More)
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2009
2009
Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.
There is a critical need for compounds that target cell surface integrin receptors for applications in cancer therapy and… (More)
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2009
2009
Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein
Cystine-knot miniproteins (knottins) are promising molecular scaffolds for protein engineering applications. Members of the… (More)
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Highly Cited
2008
Highly Cited
2008
KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
The KNOTTIN database provides standardized information on the small disulfide-rich proteins with a knotted topology called… (More)
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2007
2007
Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists.
Thrombopoietin is the primary regulator of platelet production. We exploited two naturally occurring miniproteins of the… (More)
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1998
1998
Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage.
Knottins are a group of small, disulphide-bonded proteins that bind with high specificity to their target molecules. These… (More)
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