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Cystine-Knot Miniproteins

Known as: Knottins, Cystine Knot Miniproteins, Knottin 
A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Development and Preclinical Validation of a Cysteine Knottin Peptide Targeting Integrin αvβ6 for Near-infrared Fluorescent-guided Surgery in Pancreatic Cancer
Purpose: Intraoperative near-infrared fluorescence (NIRF) imaging could help stratification for the proper primary treatment for… 
2018
2018
Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.
Gating modifier toxins from spider venom are disulfide-rich peptides that typically comprise a stabilizing inhibitor cystine knot… 
Review
2014
Review
2014
Cystine-knot peptides: emerging tools for cancer imaging and therapy
Cystine-knot miniproteins, also known as knottins, constitute a large family of structurally related peptides with diverse amino… 
2014
2014
A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging
A divalent knottin containing two separate integrin binding epitopes (RGD) in the adjacent loops, 3-4A, was recently developed… 
2013
2013
Cysteine-rich toxins from Lachesana tarabaevi spider venom with amphiphilic C-terminal segments.
2013
2013
Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein.
Ligand affinities can be optimized by interfacial cavity filling. A hollow (Phe43 cavity) between HIV-1 surface glycoprotein… 
2011
2011
Resonance condition of a microfiber knot resonator immersed in liquids.
Effects of immersing a microfiber knot resonator (MKR) in liquid solutions that have refractive indices close to that of silica… 
Review
2011
Review
2011
Diagnosis and therapy are walking together on radiopeptides’ avenue
Peptides (from the Greek πeπτίδια, “small digestibles”) are short polymers formed from the linking, in a defined order, of two or… 
2004
2004
Synthetic bivalent CD4-mimetic miniproteins show enhanced anti-HIV activity over the monovalent miniprotein.
HIV-1 envelope glycoprotein gp120 is displayed as a trimeric complex on the surface of virion and infected T-cells, making it a… 
Review
2000
Review
2000
Engineering novel bioactive mini-proteins from small size natural and de novo designed scaffolds.
Mini-proteins, polypeptides containing less than 100 amino acids, such as (animal toxins, protease inhibitors, knottins, zinc… 
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