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Molecular imaging in living subjects: seeing fundamental biological processes in a new light.
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Molecular imaging of cancer with positron emission tomography
- S. Gambhir
- Medicine, BiologyNature Reviews Cancer
- 1 September 2002
Positron emission tomography is a highly sensitive non-invasive technology that is ideally suited for pre-clinical and clinical imaging of cancer biology, in contrast to anatomical approaches.
Nanoparticle PEGylation for imaging and therapy.
A background to investigators new to stealth nanoparticles is presented, and some key considerations needed prior to designing a nanoparticle PEGylation protocol and characterizing the performance features of the product are suggested.
A molecular imaging primer: modalities, imaging agents, and applications.
This review of molecular imaging of intact living subjects focuses specifically on small molecules, peptides, aptamers, engineered proteins, and nanoparticles and cites examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics.
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.
In patients presenting with cognitive symptoms of dementia, regional brain metabolism was a sensitive indicator of AD and of neurodegenerative disease in general and a negative PET scan indicated that pathologic progression of cognitive impairment during the mean 3-year follow-up was unlikely to occur.
AMIDE: a free software tool for multimodality medical image analysis.
Amide's a Medical Image Data Examiner (AMIDE) has been developed as a user-friendly, open-source software tool for displaying and analyzing multimodality volumetric medical images and on-demand data reslicing implemented within the program.
Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output.
- A. Loening, T. Fenn, A. Wu, S. Gambhir
- BiologyProtein engineering, design & selection : PEDS
- 1 September 2006
Variants of Renilla luciferase, which exhibit significantly improved properties compared with the native enzyme, will allow enhanced sensitivity in existingLuciferase-based assays as well as enable the development of novel probes labeled with the luciferases protein.
Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
The in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs) opens up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
Self-illuminating quantum dot conjugates for in vivo imaging
- Min-kyung So, Chenjie Xu, A. Loening, S. Gambhir, J. Rao
- Chemistry, BiologyNature Biotechnology
- 1 March 2006
Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 103 for 5 pmol of conjugate.