Cystine-knot peptides: emerging tools for cancer imaging and therapy.

@article{Ackerman2014CystineknotPE,
  title={Cystine-knot peptides: emerging tools for cancer imaging and therapy.},
  author={Shelley E. Ackerman and Nicolas V Currier and Jamie M. Bergen and Jennifer R. Cochran},
  journal={Expert review of proteomics},
  year={2014},
  volume={11 5},
  pages={
          561-72
        }
}
Cystine-knot miniproteins, also known as knottins, constitute a large family of structurally related peptides with diverse amino acid sequences and biological functions. Knottins have emerged as attractive candidates for drug development as they potentially fill a niche between small molecules and protein biologics, offering drug-like properties and the ability to bind to clinical targets with high affinity and selectivity. Due to their extremely high stability and unique structural features… CONTINUE READING
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