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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
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The Future of Peptide‐based Drugs
The suite of currently used drugs can be divided into two categories – traditional ‘small molecule’ drugs with typical molecular weights of <500 Da but with oral bioavailability, and much larger…
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Conopeptide characterization and classifications: an analysis using ConoServer.
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Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.
TLDR
The structural features of the two apparent subfamilies of the CCK peptides which may be significant for the likely defense related role of these peptides within plants are defined.
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Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.
TLDR
A series of small molecules derived from the C-terminus of C5a are described, some of which are the most potent low-molecular-weight C 5a receptor antagonists reported to date for the human polymorphonuclear leukocyte (PMN) C5A receptor.
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ConoServer, a database for conopeptide sequences and structures
TLDR
ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus, which have an exceptional diversity of sequences and chemical modifications that make them important as drug leads and tools for physiological studies.
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Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*
TLDR
In electrophysiological studies, ω-conotoxins CVID and MVIIA had similar potencies to inhibit current through central and peripheral splice variants of the rat N-type calcium channels when coexpressed with rat β3 in Xenopus oocytes, but the potency of CVID increased when α1B-d and α1b-b were expressed in the absence of ratβ3.
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ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
TLDR
Automatically updated statistics on classification schemes, three-dimensional structures, conopeptide-bearing species and endoplasmic reticulum signal sequence conservation trends, provide a convenient overview of current knowledge on conopePTides.
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Protein disulfide isomerase: the structure of oxidative folding.
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Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis
TLDR
A potent inhibitory effect on the growth and development of larvae from the Lepidopteran species Helicoverpa punctigera is described, indicating that the cyclotide domains are excised and cyclized from all four predicted precursor proteins.
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