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Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
- M. Feldhaus, R. W. Siegel, +10 authors K. Wittrup
- Medicine, Biology
- Nature Biotechnology
- 1 February 2003
A nonimmune library of 109 human antibody scFv fragments has been cloned and expressed on the surface of yeast, and nanomolar-affinity scFvs routinely obtained by magnetic bead screening and… Expand
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers.
A series of novel chemically defined soluble oligomers of the human MHC class II protein HLA-DR1 was constructed to probe the molecular requirements for initiation of T cell activation. MHC dimers,… Expand
The impact of functional health literacy and acculturation on the oral health status of Somali refugees living in Massachusetts.
- P. Geltman, J. Adams, +5 authors M. Paasche-Orlow
- American journal of public health
- 10 July 2013
OBJECTIVES We assessed the impact of health literacy and acculturation on oral health status of Somali refugees in Massachusetts. METHODS Between December 2009 and June 2011, we surveyed 439 adult… Expand
Thermal conductivity and diffusivity of biomaterials measured with self-heated thermistors
This paper presents an experimental method to measure the thermal conductivity and thermal diffusivity of biomaterials. Self-heated thermistor probes, inserted into the tissue of interest, are used… Expand
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
Checkpoint blockade with antibodies specific for cytotoxic T lymphocyte–associated protein (CTLA)-4 or programmed cell death 1 (PDCD1; also known as PD-1) elicits durable tumor regression in… Expand
Engineering growth factors for regenerative medicine applications.
- Aaron C Mitchell, P. Briquez, J. Hubbell, J. Cochran
- Medicine, Engineering
- Acta biomaterialia
- 15 January 2016
UNLABELLED Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in… Expand
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
- T. J. Garrett, A. Burgess, +25 authors T. Johns
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 March 2009
Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on… Expand
Measurements of translation initiation from all 64 codons in E. coli
Abstract Our understanding of translation underpins our capacity to engineer living systems. The canonical start codon (AUG) and a few near-cognates (GUG, UUG) are considered as the ‘start codons’… Expand
Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides
- J. Willmann, Richard H. Kimura, N. Deshpande, A. Lutz, J. Cochran, S. Gambhir
- Journal of Nuclear Medicine
- 1 March 2010
Targeted contrast-enhanced ultrasound imaging is increasingly being recognized as a powerful imaging tool for the detection and quantification of tumor angiogenesis at the molecular level. The… Expand
Fine epitope mapping of anti-epidermal growth factor receptor antibodies through random mutagenesis and yeast surface display.
Fine epitope mapping of therapeutically relevant monoclonal antibodies (mAbs) specific for the epidermal growth factor receptor (EGFR) was accomplished through random mutagenesis and yeast surface… Expand