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Tumors develop through successive stages characterized by changes in gene expression and protein function. Gene expression… Expand Atherosclerosis is an inflammatory disease characterized by extensive remodeling of the extracellular matrix architecture of the… Expand Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their… Expand Cysteine proteases play numerous indispensable roles in the biology of parasitic organisms. Aside from previously known general… Expand Lysosomal cysteine proteases were believed to be mainly involved in intracellular protein degradation. Under special conditions… Expand Programmed cell death (PCD) is a process by which cells in many organisms die. The basic morphological and biochemical features… Expand SUMMARY Proteases represent the class of enzymes which occupy a pivotal position with respect to their physiological roles as… Expand Cysteine proteases have traditionally been viewed as lysosomal mediators of terminal protein degradation. However, recent… Expand Physiological levels of shear stress alter the genetic programm of cultured endothelial cells and are associated with reduced… Expand Evidence is presented, based on sequence comparison and secondary structure prediction, of structural and evolutionary… Expand