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CASP10 protein, human

Known as: MCH4, Cysteine Protease, ALPS2 
Caspase-10 (521 aa, ~59 kDa) is encoded by the human CASP10 gene. This protein plays a role in proteolysis, apoptosis induction and immunity.
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
The lowest free-energy conformations are identified by structure clustering. A second round of assembly simulation is conducted… Expand
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Highly Cited
2006
Highly Cited
2006
Background Lung cancer is the leading cause of cancer-related death in the United States. Nearly 50% of patients with stages I… Expand
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Highly Cited
2004
Highly Cited
2004
Approximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds… Expand
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Highly Cited
2002
Highly Cited
2002
Caspase 10 (Mch4/FLICE2) is a caspase homologous to caspase 8. A recent report described that inherited CASP10 gene mutations… Expand
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Highly Cited
2001
Highly Cited
2001
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a TNF family member and potent apoptosis inducer. In… Expand
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Review
1999
Review
1999
The rapid discovery of a great number of caspases, together with multiple control points of their activation, proceeds well ahead… Expand
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Highly Cited
1998
Highly Cited
1998
Although the commonly activated death protease caspase-3 appears not to be essential for apoptosis during development except in… Expand
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Highly Cited
1997
Highly Cited
1997
CASP-8 and CASP-10, members of a cysteine protease family that participates in apoptosis, interact with MORT1/FADD, an adapter… Expand
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Highly Cited
1996
Highly Cited
1996
Emerging evidence suggests that an amplifiable protease cascade consisting of multiple aspartate specific cysteine proteases… Expand
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Highly Cited
1996
Highly Cited
1996
The Fas/APO-1-receptor associated cysteine protease Mch5 (MACH/FLICE) is believed to be the enzyme responsible for activating a… Expand
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