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Cathepsin L

Known as: Cathepsin L1, Major Excreted Protein, CATL 
A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY… 
National Institutes of Health

Related topics

Related topics

21 relations
CTSL geneCTSV geneCysteine ProteasesEnzyme Gene

Narrower (3)

CTSL1 protein, humanCtsl protein, mouseCtsl protein, rat

Broader (1)

caspase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Kinetoplastid papain-like cysteine peptidases.
Highly Cited
2004
Highly Cited
2004
Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis.
Highly Cited
2000
Highly Cited
2000
Membrane topology of the Mep/Amt family of ammonium transporters
The Mep/Amt proteins constitute a new family of transport proteins that are ubiquitous in nature. Members from bacteria, yeast… 
Highly Cited
1995
Highly Cited
1995
Mature cathepsin L is substantially active in the ionic milieu of the extracellular medium.
The activity of cathepsin L is affected by ionic strength, resulting in the measured pH optimum being higher in acetate-4… 
Highly Cited
1994
Highly Cited
1994
The proregion of cathepsin L is required for proper folding, stability, and ER exit.
To investigate the role of the proregion in the biosynthesis and trafficking of mouse cathepsin L, cathepsin L cDNAs encoding… 
Highly Cited
1990
Highly Cited
1990
Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.
The degradative actions of cathepsins L and B on human articular-cartilage proteoglycan aggregates were examined. Cathepsin L was… 
Highly Cited
1989
Highly Cited
1989
Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomes.
Highly Cited
1988
Highly Cited
1988
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B.
A series of peptidyldiazomethanes was synthesized and tested as inactivators of the cysteine proteinases calpain II, cathepsin L… 
Highly Cited
1987
Highly Cited
1987
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L.
The major excreted protein (MEP) purified from Kirsten-virus-transformed 3T3 fibroblasts and mature human cathepsin L were… 
Highly Cited
1980
Highly Cited
1980
Purification and some properties of a myofibrillar protein-degrading protease, cathepsin L, from rabbit skeletal muscle.
A newly-identified muscle protease which degraded myosin, alpha-actinin, and actin, and removed the Ca-sensitivity of the ATPase… 
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