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PII Signal Transduction Proteins, Pivotal Players in Microbial Nitrogen Control
SUMMARY The PII family of signal transduction proteins are among the most widely distributed signal proteins in the bacterial world. First identified in 1969 as a component of the glutamineExpand
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Membrane sequestration of the signal transduction protein GlnK by the ammonium transporter AmtB
The Amt proteins are ammonium transporters that are conserved throughout all domains of life, being found in bacteria, archaea and eukarya. In bacteria and archaea, the Amt structural genes (amtB)Expand
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The crystal structure of the Escherichia coli AmtB–GlnK complex reveals how GlnK regulates the ammonia channel
Amt proteins are ubiquitous channels for the conduction of ammonia in archaea, eubacteria, fungi, and plants. In Escherichia coli, previous studies have indicated that binding of the PII signalExpand
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The signal transduction protein GlnK is required for NifL-dependent nitrogen control of nif gene expression in Klebsiella pneumoniae.
In Klebsiella pneumoniae, transcription of the nitrogen fixation (nif) genes is regulated in response to molecular oxygen or availability of fixed nitrogen by the coordinated activities of the nifAExpand
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The glnKamtB operon. A conserved gene pair in prokaryotes.
G.T. and M.M. were supported by EU Contract No. BIO4 CT 972310 and G.C. acknowledges a BBSRC studentship. We thank S. Austin, R. Dixon and G. Sawers for constructive comments on the manuscript.
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The 1.3-Å resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins
  • D. Lupo, X. Li, +5 authors F. Winkler
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 4 December 2007
The Rhesus (Rh) proteins are a family of integral membrane proteins found throughout the animal kingdom that also occur in a number of lower eukaryotes. The significance of Rh proteins derives fromExpand
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Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
BackgroundGlnR is an atypical response regulator found in actinomycetes that modulates the transcription of genes in response to changes in nitrogen availability. We applied a global in vivo approachExpand
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Two Residues in the T-loop of GlnK Determine NifL-dependent Nitrogen Control of nif Gene Expression*
X-ray crystallographic analysis of theEscherichia coli PII protein paralogues GlnB and GlnK has shown that they share a superimposable structural core but can differ in conformation of the T-loop, aExpand
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Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB
The conduction mechanism of Escherichia coli AmtB, the structurally and functionally best characterized representative of the ubiquitous Amt/Rh family, has remained controversial in several aspects.Expand
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Ammonium Sensing in Escherichia coli
The Amt proteins are high affinity ammonium transporters that are conserved in all domains of life. In bacteria and archaea the Amt structural genes (amtB) are invariably linked to glnK, whichExpand
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