Cathepsins B

Known as: CTSB, APP Secretase, Cathepsin B [Chemical/Ingredient] 
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Multiple types of degradative enzymes, including cathepsins of the cysteine protease family, have been implicated in the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Increasing evidence suggests that lysosomal proteases are actively involved in apoptosis. Using HeLa cells as the model system… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Thyroid function depends on processing of the prohormone thyroglobulin by sequential proteolytic events. From in vitro analysis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor… (More)
  • table I
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD). However, only a minority of smokers… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Autodigestion of the pancreas by its own prematurely activated digestive proteases is thought to be an important event in the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes… (More)
  • figure 1
  • table I
  • table II
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1982
Highly Cited
1982
1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5 mM had no effect on the serine… (More)
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?