Cystathionine beta-Synthase

Known as: L-Serine hydro-lyase (adding homocysteine), methylcysteine synthase, Sulfhydrase, Serine 
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase… (More)
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Highly Cited
2005
Highly Cited
2005
Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine. A deficiency of CBS… (More)
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Highly Cited
2004
Highly Cited
2004
Hydrogen sulfide (H2S) has been observed in relatively high concentrations in the mammalian brain and has been shown to act as a… (More)
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Highly Cited
2004
Highly Cited
2004
Hyperhomocysteinemia (HHCY) is a consequence of impaired methionine/cysteine metabolism and is caused by deficiency of vitamins… (More)
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Highly Cited
2001
Highly Cited
2001
Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent… (More)
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Highly Cited
2001
Highly Cited
2001
An inborn error of metabolism, homocystinuria due to cystathionine beta-synthase deficiency, results in markedly elevated levels… (More)
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Review
1999
Review
1999
The major cause of homocystinuria is mutation of the gene encoding the enzyme cystathionine beta-synthase (CBS). Deficiency of… (More)
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1998
1998
We have screened a rat brain library to identify proteins which interact with the 5'-end of huntingtin (amino acids 1-171… (More)
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Highly Cited
1995
Highly Cited
1995
Studies by various investigators have indicated that elevated levels of plasma homocyst(e)ine are strongly associated with the… (More)
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Highly Cited
1992
Highly Cited
1992
We elucidated the structure and alternative splicing patterns of the rat cystathionine beta-synthase gene. The gene is 20-25… (More)
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