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Cystathionine beta-Synthase

Known as: L-Serine hydro-lyase (adding homocysteine), methylcysteine synthase, Sulfhydrase, Serine 
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to… 
National Institutes of Health

Related topics

Related topics

12 relations
CBS geneHomocystinuriaIn BloodProcess of secretion

Narrower (1)

Cystathionine Beta-Synthase, human

Broader (1)

Hydro-Lyases

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cystathionine beta-synthase is enriched in the brains of Down's patients.
Down's syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation, and adults with DS develop Alzheimer… 
Review
2005
Review
2005
Heme-thiolate proteins.
Review
2005
Review
2005
The role of cystathionine beta-synthase in homocysteine metabolism.
Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and… 
Review
2003
Review
2003
Reaction mechanism and regulation of cystathionine beta-synthase.
In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the… 
Highly Cited
2001
Highly Cited
2001
Functional Properties of the Active Core of Human Cystathionine β-Synthase Crystals*
Human cystathionine β-synthase is a pyridoxal 5′-phosphate enzyme containing a heme binding domain and anS-adenosyl-l-methionine… 
Highly Cited
1998
Highly Cited
1998
Biochemistry and molecular genetics of cystathionine β-synthase deficiency
Abstract Homocysteine is an independent risk factor for arteriosclerotic disease. Deficiency of cystathionine β-synthase (CBS) is… 
Highly Cited
1993
Highly Cited
1993
Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
Homocysteine can be methylated to form methionine by the cobalamin- (Cbl) and folate-dependent enzyme, methionine synthase; serum… 
Review
1970
Review
1970
Formation, functions and regulatory importance of S-adenosyl-L-methionine.
Highly Cited
1964
Highly Cited
1964
Homocystinuria due to Cystathionine Synthetase Deficiency: The Mode of Inheritance
Deficiency of cystathioninie synthetase activity results in the clinical syndrome of homocystinuria. In both parents of a patient… 
Highly Cited
1959
Highly Cited
1959
An enzyme that synthesizes cystathionine and deaminates L-serine.
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