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Cystathionine Beta-Synthase, human

Known as: Serine Sulfhydrase, EC 4.2.1.22, Cystathionine Beta-Synthase 
Cystathionine beta-synthase (551 aa, ~61 kDa) is encoded by the human CBS gene. This protein plays a role in homocysteine metabolism.
National Institutes of Health

Related topics

Related topics

10 relations
Amino Acid BiosynthesisCBS geneCatabolic ProcessCell Nucleus

Broader (1)

Cystathionine beta-Synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity.
Highly Cited
2008
Highly Cited
2008
Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide.
Our recent study (Prathapasinghe GA, Siow YL, O K. Am J Physiol Renal Physiol 292: F1354-F1363, 2007) indicates that homocysteine… 
Review
2006
Review
2006
Biochemistry of homocysteine in health and diseases.
The amino acid homocysteine (Hcy), formed from methionine has profound importance in health and diseases. In normal circumstances… 
Highly Cited
2006
Highly Cited
2006
Hyperhomocysteinemia inhibits post-injury reendothelialization in mice.
Review
2003
Review
2003
Reaction mechanism and regulation of cystathionine beta-synthase.
In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the… 
2002
2002
The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats.
We studied the effect of troglitazone on the plasma concentrations of homocysteine (tHcy), the erythrocyte and hepatic… 
Review
2002
Review
2002
Gene Polymorphism and Coronary Risk Factors in Indian Population
Abstract Asian Indians who have settled overseas and those in urban India have increased risk of coronary events. Reasons for… 
Highly Cited
2001
Highly Cited
2001
Functional Properties of the Active Core of Human Cystathionine β-Synthase Crystals*
Human cystathionine β-synthase is a pyridoxal 5′-phosphate enzyme containing a heme binding domain and anS-adenosyl-l-methionine… 
2000
2000
Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies.
Human cystathionine beta-synthase is one of two key enzymes involved in intracellular metabolism of homocysteine. It catalyzes a… 
1990
1990
Early signs of vascular disease in homocystinuria: a noninvasive study by ultrasound methods in eight families with cystathionine-beta-synthase deficiency.
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