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Cystathionine Beta-Synthase, human

Known as: Serine Sulfhydrase, EC 4.2.1.22, Cystathionine Beta-Synthase 
Cystathionine beta-synthase (551 aa, ~61 kDa) is encoded by the human CBS gene. This protein plays a role in homocysteine metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5'-phosphate (PLP)-dependent… Expand
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Review
2009
Review
2009
•  Introduction •  Reactive nitrogen species (RNS) in the heart and vasculature •  (H2S) biosynthesis •  H2S measurement… Expand
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Highly Cited
2007
Highly Cited
2007
Hydrogen sulfide is an endogenous mediator that relaxes vascular smooth muscle, exhibits several antiinflammatory activities, and… Expand
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Highly Cited
2006
Highly Cited
2006
The transsulfuration pathway converts homocysteine to cysteine and represents the metabolic link between antioxidant and… Expand
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Highly Cited
2003
Highly Cited
2003
Although hyperhomocysteinemia is an independent risk factor for cardiovascular disease, a direct role for homocysteine (Hcy) in… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS Low folate intake may increase risk for colorectal cancer by inducing DNA hypomethylation. This study reports… Expand
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Highly Cited
2002
Highly Cited
2002
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain… Expand
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Highly Cited
2001
Highly Cited
2001
Cystathionine β‐synthase (CBS) is a unique heme‐ containing enzyme that catalyzes a pyridoxal 5′‐phosphate (PLP)‐dependent… Expand
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Highly Cited
1996
Highly Cited
1996
Mild hyperhomocysteinaemia is a major risk factor for vascular disease and neural tube defects (NTDs), conferring an… Expand
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Highly Cited
1984
Highly Cited
1984
Using an in vitro system which contained enzymes, substrates, and other reactants at concentrations which approximated the in… Expand
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