Cystathionine Beta-Synthase, human

Known as: Serine Sulfhydrase, EC 4.2.1.22, Cystathionine Beta-Synthase 
Cystathionine beta-synthase (551 aa, ~61 kDa) is encoded by the human CBS gene. This protein plays a role in homocysteine metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase… (More)
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Highly Cited
2005
Highly Cited
2005
Hydrogen sulfide (H2S) is a naturally occurring gas with potent vasodilator activity. Cystathionine-gamma-lyase (CSE) and… (More)
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Highly Cited
2004
Highly Cited
2004
Hyperhomocysteinemia (HHCY) is a consequence of impaired methionine/cysteine metabolism and is caused by deficiency of vitamins… (More)
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Highly Cited
2003
Highly Cited
2003
Although hyperhomocysteinemia is an independent risk factor for cardiovascular disease, a direct role for homocysteine (Hcy) in… (More)
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Highly Cited
2001
Highly Cited
2001
Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent… (More)
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Highly Cited
2001
Highly Cited
2001
Hyperhomocysteinemia is associated with increased risk for cardiovascular events, but it is not certain whether it is a mediator… (More)
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Highly Cited
2001
Highly Cited
2001
Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of… (More)
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Highly Cited
1998
Highly Cited
1998
Human cystathionine beta-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine. It is… (More)
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1998
1998
We have screened a rat brain library to identify proteins which interact with the 5'-end of huntingtin (amino acids 1-171… (More)
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1998
1998
Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a… (More)
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