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Cyclin-Dependent Kinase Inhibitor Agents

Known as: CDK Inhibitor, CDKI, Cyclin-Dependent Kinase Inhibitor 
Any substance that inhibits cyclin-dependent kinase (CDK), an enzyme that catalyzes the addition of a phosphate group to a protein in the cell cycle… 
National Institutes of Health

Related topics

Related topics

3 relations
CDKN3 geneCyclin-Dependent Kinase Inhibitor Proteinscyclin-dependent protein kinase inhibitor activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase
The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial… 
Highly Cited
2005
Highly Cited
2005
Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers
SummaryFamilial breast cancers that are associated with BRCA1 or BRCA2 germline mutations differ in both their morphological and… 
Highly Cited
2004
Highly Cited
2004
BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells
Prostate cancer is one of the most common cancers in men. Several lines of evidence have suggested that bone morphogenetic… 
Highly Cited
2004
Highly Cited
2004
Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat.
Proliferation and differentiation of satellite cells are critical in the regeneration of atrophied muscle following… 
Highly Cited
2004
Highly Cited
2004
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Bladder cancer is the fourth and eighth most common cancer in men and women in the USA, respectively. Flavonoid phytochemicals… 
Review
2003
Review
2003
PTEN signaling pathways in melanoma
Phosphatase and tensin homolog deleted in from chromosome ten (PTEN), initially also known as mutated in multiple advanced… 
Highly Cited
2000
Highly Cited
2000
Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells.
The mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor (CDKI) genes, the p21, p27, and p57 genes, in… 
Highly Cited
1998
Highly Cited
1998
A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145…
Prostate cancer (PCA) is the most common nonskin malignancy and the second leading cause of cancer deaths in United States males… 
Highly Cited
1997
Highly Cited
1997
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
The activity of the cyclin-dependent kinases (CDKs) that control cell growth and division can be negatively regulated by tyrosine… 
Highly Cited
1996
Highly Cited
1996
Alterations of the p15, p16,and p18 genes in osteosarcoma.
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