Cyclin-Dependent Kinase Inhibitor Agents

Known as: CDK Inhibitor, CDKI, Cyclin-Dependent Kinase Inhibitor 
Any substance that inhibits cyclin-dependent kinase (CDK), an enzyme that catalyzes the addition of a phosphate group to a protein in the cell cycle… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
CONTEXT Germline mutation in the MEN1 gene is the usual cause of multiple endocrine neoplasia type 1 (MEN1). However, the… (More)
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2006
2006
The circadian timing system and the cell division cycle are frequently deregulated in cancer. The therapeutic relevance of the… (More)
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Highly Cited
2005
Highly Cited
2005
The Forkhead box m1 (Foxm1) gene is critical for G(1)/S transition and essential for mitotic progression. However, the… (More)
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Highly Cited
2004
Highly Cited
2004
Familial breast cancers that are associated with BRCA1 or BRCA2 germline mutations differ in both their morphological and… (More)
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Highly Cited
2004
Highly Cited
2004
Bladder cancer is the fourth and eighth most common cancer in men and women in the USA, respectively. Flavonoid phytochemicals… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECT Ionizing radiation is the gold-standard adjuvant treatment for glioblastoma multiforme (GBM), the most aggressive primary… (More)
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Highly Cited
2000
Highly Cited
2000
We investigated the in vitro effect of As2O3 on proliferation, cell cycle regulation, and apoptosis in human myeloma cell lines… (More)
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Highly Cited
2000
Highly Cited
2000
The mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor (CDKI) genes, the p21, p27, and p57 genes, in… (More)
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Highly Cited
1998
Highly Cited
1998
Prostate cancer (PCA) is the most common nonskin malignancy and the second leading cause of cancer deaths in United States males… (More)
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Highly Cited
1995
Highly Cited
1995
Cyclin and cyclin-dependent kinase (CDK) complexes play important roles in controlling the cell cycle. The CDK inhibitors (CDKIs… (More)
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