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Cyclin-Dependent Kinase Inhibitor Agents

Known as: CDK Inhibitor, CDKI, Cyclin-Dependent Kinase Inhibitor 
Any substance that inhibits cyclin-dependent kinase (CDK), an enzyme that catalyzes the addition of a phosphate group to a protein in the cell cycle… 
National Institutes of Health

Related topics

Related topics

3 relations
CDKN3 geneCyclin-Dependent Kinase Inhibitor Proteinscyclin-dependent protein kinase inhibitor activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Cell cycle dysregulation in pituitary oncogenesis.
The cell cycle is the process by which cells grow, replicate their genome and divide. The cell cycle control system is a… 
2003
2003
The prognostic impact of cyclin dependent kinase inhibitors p21WAF1, p27Kip1, and p16INK4/MTS1 in adenocarcinomas of the uterine cervix
The authors assessed the prognostic significance of abnormal cyclin dependent kinase inhibitor (CDKI) expression in… 
2002
2002
Vitamin D and Its Analog EB1089 Induce p27 Accumulation and Diminish Association of p27 with Skp2 Independent of PTEN in Pituitary Corticotroph Cells
Disruption of the gene for the cyclin dependent kinase inhibitor (CDKI) p27/kip1 results in pituitary corticotroph hyperplasia… 
Highly Cited
2000
Highly Cited
2000
Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
Cyclin-dependent kinase inhibitors (CDKI) are negative regulators of cell cycle progression by binding the cyclin-CDK complex and… 
2000
2000
Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin‐dependent kinase inhibitor genes
Cyclin‐dependent kinase inhibitors play a significant role in cell cycle progression and in cellular differentiation and their… 
2000
2000
Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells.
Progression through the cell cycle is controlled by the induction of cyclins and activation of cognate cyclin-dependent kinases… 
1999
1999
Differential regulation of p27kip1 levels and CDK activities by hypertrophic and hyperplastic agents in vascular smooth muscle cells.
1998
1998
Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development.
1997
1997
Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)
The retinoblastoma susceptibility gene (Rb) plays a key role in regulating the cell cycle in association with cyclins and cyclin… 
1996
1996
Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.
Cyclin-dependent kinase inhibitors (CDKIs) can be classified into two groups based on the structure of the proteins. One group… 
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