cyclin-dependent protein kinase inhibitor activity

Known as: cyclin dependent protein kinase inhibitor activity, cyclin-dependent kinase inhibitor, cyclin dependent kinase inhibitor 
Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:mah, GOC:pr]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
020406019942018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Cyclin-dependent kinases (CDK) are key positive regulators of cell cycle progression and attractive targets in oncology. SCH… (More)
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Highly Cited
2006
Highly Cited
2006
Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of… (More)
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Highly Cited
2005
Highly Cited
2005
Cyclin-dependent kinase (CDK) inhibitors have the potential to induce cell-cycle arrest and apoptosis in cancer cells. Seliciclib… (More)
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Highly Cited
2002
Highly Cited
2002
We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor p27kip1. Blockade of HER2/neu in tumor cells… (More)
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Highly Cited
2002
Highly Cited
2002
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in… (More)
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Highly Cited
2001
Highly Cited
2001
SCF ubiquitin ligases target phosphorylated substrates for ubiquitin-dependent proteolysis by means of adapter subunits called F… (More)
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Highly Cited
1999
Highly Cited
1999
Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence… (More)
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Highly Cited
1998
Highly Cited
1998
A constitutively active form of mitogen-activated protein kinase kinase (MEK1) was synthesized under control of a zinc-inducible… (More)
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Highly Cited
1997
Highly Cited
1997
The nuclear factor kappaB (NF-kappaB) transcription factor is responsive to specific cytokines and stress and is often activated… (More)
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Highly Cited
1997
Highly Cited
1997
CDK inhibitors are thought to prevent cell proliferation by negatively regulating cyclin-CDK complexes. We propose that the… (More)
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