Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat.

@article{Dasarathy2004SkeletalMA,
  title={Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat.},
  author={Srinivasan Dasarathy and Milan Dodig and Sean M Muc and Satish C. Kalhan and Arthur Joseph McCullough},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 6},
  pages={G1124-30}
}
Proliferation and differentiation of satellite cells are critical in the regeneration of atrophied muscle following immobilization and aging. We hypothesized that impaired satellite cell function is responsible for the atrophy of skeletal muscle also seen in cirrhosis. Myostatin and insulin-like growth factor 1 (IGF1) have been identified to be positive and negative regulators, respectively, of satellite cell function. Using a rat model of cirrhosis [portacaval anastamosis (PCA)] and sham… CONTINUE READING

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