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Cyclin-Dependent Kinase Inhibitor 2A, human

Known as: Cell Cycle Negative Regulator Beta, CDKN2A-p16(INK4a), MTS1 
Cyclin-dependent kinase inhibitor 2A (156 aa, ~17 kDa) is encoded by the human CDKN2A gene. This protein is involved in the inhibition of both cell… 
National Institutes of Health

Related topics

Related topics

19 relations
CDKN2A geneCDKN2A wt AlleleCTCF PathwayCell Cycle Control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.
BACKGROUND Plasma-derived cell-free tumor DNA (ctDNA) constitutes a potential surrogate for tumor DNA obtained from tissue… 
Highly Cited
2012
Highly Cited
2012
RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors.
PURPOSE RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and… 
Highly Cited
2011
Highly Cited
2011
Human glioma growth is controlled by microRNA-10b.
MicroRNA (miRNA) expression profiling studies revealed a number of miRNAs dysregulated in the malignant brain tumor glioblastoma… 
Review
2005
Review
2005
INK4a/ARF: a multifunctional tumor suppressor locus.
Highly Cited
2004
Highly Cited
2004
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations… 
Highly Cited
2002
Highly Cited
2002
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Highly Cited
2001
Highly Cited
2001
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer… 
Highly Cited
2001
Highly Cited
2001
Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.
We investigated the aberrant promoter methylation profile of bladder cancers and correlated the data with clinicopathological… 
Highly Cited
2001
Highly Cited
2001
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumours, commonly… 
Highly Cited
1998
Highly Cited
1998
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
The p16(INK4a) (p16) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including… 
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