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Cyclin-Dependent Kinase 11B, human

Known as: CLK-1, PITSLRE A, p58/GTA Protein Kinase 
Cyclin-dependent kinase 11B (795 aa, ~93 kDa) is encoded by the human CDK11B gene. This protein is involved in the modulation of cell cycle… 
National Institutes of Health

Related topics

Related topics

27 relations
ApoptosisCDC2 Protein KinaseCDK11A geneCDK11B gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.
A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment… 
2010
2010
The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins.
The aging-associated enzyme CLK-1 is proposed to be a member of the carboxylate-bridged diiron family of proteins. To evaluate… 
Highly Cited
2009
Highly Cited
2009
The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1*
The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease is strongly age-dependent… 
Highly Cited
2007
Highly Cited
2007
Knockdown of Mitochondrial Heat Shock Protein 70 Promotes Progeria-like Phenotypes in Caenorhabditis elegans*
Mitochondrial heat shock protein 70 (mthsp70) functions as a mitochondrial import motor and is essential in mitochondrial… 
Highly Cited
2003
Highly Cited
2003
The p34 cdc2 -related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during Apoptosis*
Cyclin-dependent kinase 11 (CDK11; also named PITSLRE) is part of the large family of p34 cdc2 -related kinases whose functions… 
Review
2002
Review
2002
Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans
Review
2000
Review
2000
clk-1, mitochondria, and physiological rates.
Mutations in the C. elegans maternal-effect gene clk-1 are highly pleiotropic, affecting the duration of diverse developmental… 
Highly Cited
1999
Highly Cited
1999
Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging
Abstract. Mutations in the Caenorhabditis elegans gene clk-1 have a major effect on slowing development and increasing life span… 
Highly Cited
1998
Highly Cited
1998
Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2.
Cdc2L1 and Cdc2L2 span approximately 140 kb on human chromosome 1p36.3. The products of the Cdc2L genes encode almost identical… 
1997
1997
Molecular analysis of the region of distal 1p commonly deleted in neuroblastoma.
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