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The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Accumulating evidence indicates that elevated levels of prostaglandin E(2) (PGE(2)) can increase intestinal epithelial cell proliferation, and thus play a role in colorectal tumorigenesis. PGE(2)Expand
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Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells
The eukaryotic initiation factor 3f (eIF3f) is the p47 subunit of the multi-subunit eIF3 complex. eIF3 plays an important role in translation initiation. In the present study, we investigate theExpand
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The p34 cdc2 -related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during Apoptosis*
Cyclin-dependent kinase 11 (CDK11; also named PITSLRE) is part of the large family of p34 cdc2 -related kinases whose functions appear to be linked with cell cycle progression, tumorigenesis, andExpand
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Cytogenetics of 158 patients with regional or disseminated melanoma. Subset analysis of near-diploid and simple karyotypes.
We report on the cytogenetic analyses of 158 cases of metastatic malignant melanoma, comprised of 63 cases with regional disease (RD) and 95 cases with distant (metastatic) disease (DD). ClonalExpand
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Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines.
Selenium supplementation has been shown for many years to work as an anticarcinogenic agent both in epidemiology and in in vitro studies. Selenium supplementation has recently been shown to decreaseExpand
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A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.
AIMS Cannabinoid CB(2) agonists have been shown to alleviate behavioral signs of inflammatory and neuropathic pain in animal models. AM1241, a CB(2) agonist, does not demonstrate central nervousExpand
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The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.
We identified Ran-binding protein (RanBPM) as an interacting partner of the caspase-processed C-terminal domain of cyclin-dependent kinase 11 (CDK11(p46)) by using the yeast two-hybrid system.Expand
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Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers.
A biomarker of skin cancer would be beneficial in evaluating the efficacy of potential cancer chemoprevention agents. To this end, we investigated the tumor suppressor gene p53 in precancerousExpand
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Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors.
An activated Ha-ras oncogene has been consistently found in chemically initiated benign and malignant mouse skin tumors, and an activated ras oncogene has been shown to initiate the process of mouseExpand
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Chemoprevention of prostate cancer with selenium: An update on current clinical trials and preclinical findings
Prostate cancer is the most common cancer diagnosed and the second leading cause of cancer‐related deaths in men in the United States. The etiological factors that give rise to prostate cancer areExpand
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