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Cuprizone

Known as: Oxaldihydrazone, Biscyclohexanone, Cuprizone [Chemical/Ingredient], Ethanedioic acid, bis(cyclohexylidenehydrazide) 
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Recent evidence suggests that astrocytes play an important role in regulating de- and remyelination in multiple sclerosis. The… Expand
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Highly Cited
2010
Highly Cited
2010
Multiple sclerosis is an inflammatory demyelinating disorder of the CNS. Recent studies have suggested diverse mechanisms as… Expand
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Highly Cited
2009
Highly Cited
2009
Cuprizone feeding is a commonly used model to study experimental de- and remyelination, with the corpus callosum being the most… Expand
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Highly Cited
2009
Highly Cited
2009
Sex hormones, for example, estrogen and progesterone, are thought to affect and delay progression of multiple sclerosis (MS) in… Expand
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Highly Cited
2008
Highly Cited
2008
The cuprizone model of toxic demyelination in the central nervous system is commonly used to investigate the pathobiology of… Expand
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Highly Cited
2007
Highly Cited
2007
The neurotoxicant cuprizone has been used extensively to create a mouse model of demyelination. However, the effects on behavior… Expand
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Highly Cited
2006
Highly Cited
2006
Previously, we tested the prediction that axonal damage results in decreased axial diffusivity (lambda(parallel)) while… Expand
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Highly Cited
2005
Highly Cited
2005
Myelin damage, as seen in multiple sclerosis (MS) and other demyelinating diseases, impairs axonal conduction and can also be… Expand
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Highly Cited
2003
Highly Cited
2003
The demyelinating toxin cuprizone is used increasingly in mouse studies of central nervous system remyelination. The value of… Expand
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Highly Cited
1998
Highly Cited
1998
To study microglial/macrophage infiltration, a cuprizone-induced model for demyelination in C57BL/6 mice was established… Expand
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