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Cuprizone

Known as: Oxaldihydrazone, Biscyclohexanone, Cuprizone [Chemical/Ingredient], Ethanedioic acid, bis(cyclohexylidenehydrazide) 
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

Chelating AgentsMonoamine Oxidase Inhibitors
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Although astrogliosis and microglia activation are characteristic features of multiple sclerosis (MS) and other central nervous… 
Highly Cited
2013
Highly Cited
2013
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.
Recent evidence suggests that astrocytes play an important role in regulating de- and remyelination in multiple sclerosis. The… 
Highly Cited
2010
Highly Cited
2010
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis
Multiple sclerosis is an inflammatory demyelinating disorder of the CNS. Recent studies have suggested diverse mechanisms as… 
Review
2009
Review
2009
The cuprizone animal model: new insights into an old story
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents… 
Review
2008
Review
2008
The cuprizone model for demyelination
Background –  Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments… 
Highly Cited
2008
Highly Cited
2008
Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
The cuprizone model of toxic demyelination in the central nervous system is commonly used to investigate the pathobiology of… 
Highly Cited
2006
Highly Cited
2006
Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
Previously, we tested the prediction that axonal damage results in decreased axial diffusivity (λ∥) while demyelination leads to… 
Highly Cited
2005
Highly Cited
2005
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Review
2001
Review
2001
The Neurotoxicant, Cuprizone, as a Model to Study Demyelination and Remyelination in the Central Nervous System
Myelin of the adult CNS is vulnerable to a variety of metabolic, toxic, and autoimmune insults. That remyelination can ensue… 
Highly Cited
1998
Highly Cited
1998
Gene Expression in Brain during Cuprizone-Induced Demyelination and Remyelination
When C57BL/6J mice, 8 weeks of age, received 0.2% Cuprizone in their diet, extensive demyelination in corpus callosum was… 
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