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Cuprizone

Known as: Oxaldihydrazone, Biscyclohexanone, Cuprizone [Chemical/Ingredient], Ethanedioic acid, bis(cyclohexylidenehydrazide) 
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

Chelating AgentsMonoamine Oxidase Inhibitors
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Toxicity of cuprizone a Cu2+ chelating agent on isolated mouse brain mitochondria: a justification for demyelination and subsequent behavioral dysfunction
Abstract Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective cure, despite decades of… 
2012
2012
Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination
Highly Cited
2011
Highly Cited
2011
Dietary Vitamin D3 Supplements Reduce Demyelination in the Cuprizone Model
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and… 
Highly Cited
2010
Highly Cited
2010
Cerebellar Cortical Demyelination in the Murine Cuprizone Model
In multiple sclerosis, demyelination occurs beside the white‐matter structures and in the cerebral and cerebellar cortex. We have… 
Highly Cited
1996
Highly Cited
1996
Decomposition of S-nitrosoglutathione in the presence of copper ions and glutathione.
The decomposition of S-nitrosoglutathione (GSNO) in the presence of Cu2+ and glutathione (GSH) was studied by stopped-flow/rapid… 
Highly Cited
1992
Highly Cited
1992
Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.
To investigate insulin-like growth factor I (IGF-I) and IGF-I receptor gene expression during experimental demyelination and… 
Highly Cited
1982
Highly Cited
1982
Monoamine oxidase activities in brown adipose tissue of the rat: some properties and subcellular distribution.
Highly Cited
1979
Highly Cited
1979
ULTRASTRUCTURAL CHANGES OF OLIGODENDROGLIA AND MYELIN SHEATHS INDUCED BY ETHIDIUM BROMIDE
Yajima K. & Suzuki K. (1979) Neurobiology and Applied Neuropathology5, 49–62 
Highly Cited
1973
Highly Cited
1973
DIVISION OF GIANT MITOCHONDRIA DURING RECOVERY FROM CUPRIZONE INTOXICATION
Giant mitochondria may be induced in mouse hepatocytes either by riboflavin deficiency (30) or by addition of the copper… 
Highly Cited
1969
Highly Cited
1969
Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone).
STATUS SPONGIOSuS has been found in the brain in varioyus neurologic disorders.1 Although, at the light microscopic leveL the… 
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