Cuprizone

Known as: Oxaldihydrazone, Biscyclohexanone, Cuprizone [Chemical/Ingredient], Ethanedioic acid, bis(cyclohexylidenehydrazide) 
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2018
0102019722018

Papers overview

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2011
2011
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and… (More)
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2010
Highly Cited
2010
Multiple sclerosis is an inflammatory demyelinating disorder of the CNS. Recent studies have suggested diverse mechanisms as… (More)
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2010
2010
Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative… (More)
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2009
Highly Cited
2009
Cuprizone feeding is a commonly used model to study experimental de- and remyelination, with the corpus callosum being the most… (More)
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2009
2009
Memory impairment is outstanding within the spectrum of cognitive deficits in multiple sclerosis (MS) patients. Demyelination has… (More)
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2006
Highly Cited
2006
Previously, we tested the prediction that axonal damage results in decreased axial diffusivity (lambda(parallel)) while… (More)
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2006
2006
In order to further characterize the still unknown mechanism of cuprizone-induced demyelination, we investigated its effect on… (More)
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Highly Cited
1998
Highly Cited
1998
To study microglial/macrophage infiltration, a cuprizone-induced model for demyelination in C57BL/6 mice was established… (More)
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1998
1998
When C57BL/6J mice, 8 weeks of age, received 0.2% Cuprizone in their diet, extensive demyelination in corpus callosum was… (More)
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1978
1978
Male weanling mice (Biobreeding Laboratories) exposed to the drug Cuprizone (biscyclohexanone, oxaldihydrazone) in the diet for… (More)
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