Reaction of peroxynitrite with HEPES or MOPS results in the formation of nitric oxide donors.

@article{Schmidt1998ReactionOP,
  title={Reaction of peroxynitrite with HEPES or MOPS results in the formation of nitric oxide donors.},
  author={K. Schmidt and S. Pfeiffer and B. Mayer},
  journal={Free radical biology \& medicine},
  year={1998},
  volume={24 5},
  pages={
          859-62
        }
}
We investigated the effects of organic buffers on the NO-like biological activities of ONOO-. In HEPES buffer (50 mM), ONOO- (1 mM) induced a 20-fold increase in endothelial cGMP accumulation and the effect was comparable to that elicited by a maximally active concentration of the NO donor DEA/NO. ONOO- produced a 12-fold increase of cGMP in MOPS buffer (50 mM), but was virtually inactive in phosphate buffer (50 mM). Electrochemical detection of NO showed that the biological effects of ONOO- in… Expand
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