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Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter
TLDR
Using a superfusion bioassay, the release of a vasorelaxant factor is reported upon stimulation of the NANC nerves in the canine ileocolonic junction, indicating that NO accounted for the biological activity of this transferable NANC factor. Expand
Therapeutic potential of helminth soluble proteins in TNBS‐induced colitis in mice
TLDR
Induction of colitis significantly increased expression of IFN‐γ mRNA in the inflamed colon and caused a decrease of proinflammatory cytokines in colon and MLN, whereas the production of regulatory cytokines increased significantly in colon tissue. Expand
Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease
TLDR
In this large cohort of infliximab-treated CD patients, young age, Crohn's colitis, and concomitant immunosuppressive treatment were identified as independent variables favoring short-term response to inflixIMab. Expand
NOD2/CARD15 does not influence response to infliximab in Crohn's disease.
TLDR
NOD2/CARD15 was not predictive of treatment outcome with infliximab in Crohn's disease, and multivariate analysis could not identify clinical characteristics that, in combination with NOD1/Card15 mutations, were associated with response to inflIXimab. Expand
Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings
TLDR
Dyspeptic symptoms are frequent in the general population, with overlapping reflux symptoms and increased symptom burden in about a third of patients, while in severe functional dyspepsia patients, symptoms are organized in factors associated with pathophysiological mechanisms. Expand
Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.
TLDR
Ghrelin and GHRP-6 but not motilin accelerate gastric emptying and transit by activating cholinergic excitatory pathways in the enteric nervous system in addition to the known vagal pathways. Expand
Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced
TLDR
Inflammation induced disturbances in contractility of longitudinal and circular colonic muscle strips may outlast the inflammatory reaction and protect against Th1 gut inflammation. Expand
Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease
TLDR
In this cohort of infliximab-treated patients, neither ASCA nor pANCA could predict response to treatment, however, the combination pAN CA+/ASCA− might warrant further investigation for its value in predicting nonresponse in patients with refractory luminal disease. Expand
Evidence for nitric oxide as mediator of non‐adrenergic, non‐cholinergic relaxations induced by ATP and GABA in the canine gut
TLDR
The results demonstrate that the ATP‐ and GABA‐induced relaxations resulting from stimulaton of intramural NANC neurones, in addition to those induced by electrical impulses, are mediated by NO or a NO releasing substance and thus provide further evidence in support of the proposal that NO is the final inhibitory NANC neurotransmitter in the canine terminal ileum and ileocolonic junction. Expand
Involvement of nitric oxide in the inhibitory innervation of the human isolated colon.
TLDR
The results suggest that NO and another substance, perhaps ATP, are involved in the inhibitory NANC neurotransmission in the circular muscle of the human colon. Expand
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