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Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

Using a superfusion bioassay, the release of a vasorelaxant factor is reported upon stimulation of the NANC nerves in the canine ileocolonic junction, indicating that NO accounted for the biological activity of this transferable NANC factor.
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Therapeutic potential of helminth soluble proteins in TNBS‐induced colitis in mice

Induction of colitis significantly increased expression of IFN‐γ mRNA in the inflamed colon and caused a decrease of proinflammatory cytokines in colon and MLN, whereas the production of regulatory cytokines increased significantly in colon tissue.
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Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease

In this large cohort of infliximab-treated CD patients, young age, Crohn's colitis, and concomitant immunosuppressive treatment were identified as independent variables favoring short-term response to inflixIMab.
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Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced…

Inflammation induced disturbances in contractility of longitudinal and circular colonic muscle strips may outlast the inflammatory reaction and protect against Th1 gut inflammation.
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Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease

In this cohort of infliximab-treated patients, neither ASCA nor pANCA could predict response to treatment, however, the combination pAN CA+/ASCA− might warrant further investigation for its value in predicting nonresponse in patients with refractory luminal disease.
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Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

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A positive response to infliximab in Crohn disease: Association with a higher systemic inflammation before treatment but not with-308 TNF gene polymorphism

A positive clinical response to infliximab was associated with a higher CRP level before treatment in the population of Crohn disease patients, but there was no relevant association with -308 TNF gene polymorphism.
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NOD2/CARD15 does not influence response to infliximab in Crohn's disease.

NOD2/CARD15 was not predictive of treatment outcome with infliximab in Crohn's disease, and multivariate analysis could not identify clinical characteristics that, in combination with NOD1/Card15 mutations, were associated with response to inflIXimab.
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Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings

Dyspeptic symptoms are frequent in the general population, with overlapping reflux symptoms and increased symptom burden in about a third of patients, while in severe functional dyspepsia patients, symptoms are organized in factors associated with pathophysiological mechanisms.
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Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats.

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