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Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter
INHIBITORY non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomie innervation of the gastrointestinal tract and other organ systems. The nature of theirExpand
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Therapeutic potential of helminth soluble proteins in TNBS‐induced colitis in mice
Background: The hygiene hypothesis suggests an inverse relationship between the incidence of parasitic infections and chronic inflammatory bowel diseases (IBD). We investigated the therapeuticExpand
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Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease
OBJECTIVE:Infliximab is an effective treatment for refractory or fistulizing Crohn's disease (CD). However, about 30% of patients do not respond to infliximab for unknown reasons. IdentifyingExpand
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Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced
Background and aims: Crohn’s disease, characterised by chronic T helper 1 (Th1) inflammation and dysmotility of the gut, is most prevalent in developed countries. Parasitic infections are mostExpand
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Involvement of nitric oxide in the inhibitory innervation of the human isolated colon.
BACKGROUND The exact nature of the inhibitory nonadrenergic noncholinergic (NANC) neurotransmitter in the human colon is still unknown. METHODS The present study was designed to investigate theExpand
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Evidence for a differential release of nitric oxide and vasoactive intestinal polypeptide by nonadrenergic noncholinergic nerves in the rat gastric fundus.
The roles of vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) in nonadrenergic noncholinergic (NANC) nerve-mediated relaxations were investigated in longitudinal muscle strips of the ratExpand
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Neuroanatomy of lower gastrointestinal pain disorders.
Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal, immune and endocrine signaling pathways within the intestines, the peripheral and theExpand
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Effect of Schistosoma mansoni-induced granulomatous inflammation on murine gastrointestinal motility.
In Schistosoma mansoni-infected mice, gastrointestinal transit was measured in vivo and the neuromuscular function of longitudinal muscle strips of inflamed ileum and noninflamed gastric fundus wasExpand
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Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease
OBJECTIVES:The use of monoclonal anti-tumor necrosis factor (TNF) antibodies (infliximab, Remicade) is a new therapeutic approach for severe refractory luminal or fistulizing, Crohn's disease (CD).Expand
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Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation
The effect of chronic intestinal inflammation on the purinergic modulation of cholinergic neurotransmission was studied in the mouse ileum. Chronic intestinal inflammation was induced by infection ofExpand
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