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Cryptophycins

Peptolides forming 16-membered macrolides, composed of two ester linkages, two amide linkages and seven asymmetric centers. They have been found in… 
National Institutes of Health

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Depsipeptides

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cryptophycin

Papers overview

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2007
2007
Characterization of the β‐Methylaspartate‐α‐decarboxylase (CrpG) from the Cryptophycin Biosynthetic Pathway
The cryptophycins are promising therapeutic agents due to their potent selectivity for cancer cells, which include multidrug… 
2006
2006
In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: Species differences and stereoselectivity
The enzyme kinetics of the glutathione (GSH) conjugation of cryptophycin 52 (C52, R-stereoisomer) and cryptophycin 53 (C53, S… 
2004
2004
Chemoselective cross metathesis of bishomoallylic alcohols: rapid access to fragment a of the cryptophycins.
[reaction: see text] The racemic or enantioselective allylation of in situ formed beta,gamma-unsaturated aldehydes provides… 
2004
2004
The nucleophilic addition of alpha-metallated 1,3-dioxanes to planar chiral cationic eta3-allylmolybdenum complexes. Synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester, a…
Two adjacent stereogenic centres and a pendant alkene were constructed via nucleophilic addition of a 1,3-dioxan-4-ylcopper(I… 
2001
2001
Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24.
[see structure]. An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been… 
2000
2000
Cryptophycin-induced hyperphosphorylation of Bcl-2, cell cycle arrest and growth inhibition in human H460 NSCLC cells
Abstract. Bcl-2 has been described as a factor that can protect from apoptosis. The protective effect of Bcl-2 may be lost if the… 
2000
2000
Cryptophycin 52 and cryptophycin 55 in sequential and simultaneous combination treatment regimens in human tumor xenografts.
The antitumor activity of cryptophycin 52 (C52) and cryptophycin 55 (C55) in sequential and simultaneous combination treatment… 
1999
1999
Synthesis of Unit A of Cryptophycin via a [2,3]-Wittig Rearrangement.
The synthesis of unit A of the cryptophycins from (S)-trans-3-penten-2-ol and from (S)-trans-4-hexen-3-ol has been completed. The… 
1998
1998
Enantioselective synthesis of a 3'-dephenylcryptophycin synthon.
1998
1998
Binding of the epoxide cryptophycin analog, LY355703 to albumin and its effect on in vitro antiproliferative activity.
Cryptophycin, isolated from the cyanobacterium Nostoc, is a cytotoxic dioxadiazacyclohexadecenetetrone which causes rapid… 
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