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cryptophycin

Known as: 10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 
The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (5)

Antifungal AgentsAntineoplastic AgentsCryptophycinsDepsipeptides
Microtubule Processcryptophycin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues
Two analogues of cryptophycin were synthesized and biologically evaluated for their in‐vitro cytotoxicities against several solid… 
2006
2006
Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid.
A hybrid structure was synthesized in which one portion is characteristic of a cryptophycin and a second sector bears the… 
2004
2004
Direct Photoaffinity Labeling by Dolastatin 10 of the Amino-terminal Peptide of β-Tubulin Containing Cysteine 12*
Tubulin with bound [5-3H]dolastatin 10 was exposed to ultraviolet light, and 8–10% of the bound drug cross-linked to the protein… 
2003
2003
Stability of drug-induced tubulin rings by fluorescence correlation spectroscopy.
Fluorescence correlation spectroscopy (FCS) was applied to investigate the stability of tubulin rings that result from the… 
2003
2003
Sulfinyl moiety as an internal nucleophile. 1. Efficient stereoselective synthesis of fragment a of cryptophycin 3.
A novel, efficient, and stereoselective synthesis of fragment A of cryptophycin 3 is disclosed. The key step involves the regio… 
2002
2002
Phase I trial of the cryptophycin analogue LY355703 administered as an intravenous infusion on a day 1 and 8 schedule every 21 days.
The cryptophycin analogue LY355703 is a potent inhibitor of microtubule polymerization that displays in vitro and in vivo… 
2001
2001
Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24.
[see structure]. An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been… 
2000
2000
A convergent synthesis of (+)-cryptophycin B, a potent antitumor macrolide from Nostoc sp. cyanobacteria.
[structure--see text] An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is… 
1999
1999
Synthesis of Unit A of Cryptophycin via a [2,3]-Wittig Rearrangement.
The synthesis of unit A of the cryptophycins from (S)-trans-3-penten-2-ol and from (S)-trans-4-hexen-3-ol has been completed. The… 
1998
1998
Enantioselective synthesis of a 3'-dephenylcryptophycin synthon.
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