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cryptophycin 1

National Institutes of Health

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Depsipeptides
cryptophycin

Papers overview

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2007
2007
Characterization of the β‐Methylaspartate‐α‐decarboxylase (CrpG) from the Cryptophycin Biosynthetic Pathway
The cryptophycins are promising therapeutic agents due to their potent selectivity for cancer cells, which include multidrug… 
2004
2004
Biological evaluation of cryptophycin 52 fragment A analogues: effect of the multidrug resistance ATP binding cassette transporters on antitumor activity.
Cryptophycin 52 (LY355703) is a potent antiproliferative analogue of the marine natural product cryptophycin 1. It has been shown… 
2002
2002
Stereospecific synthesis of cryptophycin 1.
[reaction: see text] A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the… 
Highly Cited
1999
Highly Cited
1999
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
1996
1996
Cryptophycin 1 binds to tubulin at a site distinct from the colchicine binding site and at a site that may overlap the vinca binding site.
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