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Complement Receptor Type 1

Known as: CD35, CD35 Antigen 
Complement receptor type 1 (2039 aa, ~224 kDa) is encoded by the human CR1 gene. This protein is involved in complement activation.
National Institutes of Health

Related topics

Related topics

8 relations
CR1 geneCR1 wt AlleleComplement 3b ReceptorComplement Activation

Broader (1)

Complement Receptor

Papers overview

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Highly Cited
2002
Highly Cited
2002
Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes1
The complement system—particularly component C3—has been demonstrated to be a key link between innate and adaptive immunity. The… 
Highly Cited
2001
Highly Cited
2001
Contribution of the innate immune system to autoimmune myocarditis: a role for complement
Myocarditis is a principal cause of heart disease among young adults and is often a precursor of heart failure due to dilated… 
Highly Cited
1992
Highly Cited
1992
Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat.
We examined the role of C activation in ischemia reperfusion injury by inhibiting C activation in a rat model of mesenteric… 
Highly Cited
1992
Highly Cited
1992
Protective effects of soluble CR1 in complement- and neutrophil-mediated tissue injury.
Complement activation is an important step for triggering of acute inflammatory reactions. Soluble human recombinant complement… 
Highly Cited
1991
Highly Cited
1991
THE EFFECT OF SOLUBLE COMPLEMENT RECEPTOR TYPE 1 ON HYPERACUTE XENOGRAFT REJECTION
In the guinea pig-to-rat model of hyperacute xenograft (Xg) rejection, the effect of complement inhibition using systemically… 
Highly Cited
1990
Highly Cited
1990
Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.
The complement system is an important mediator of the acute inflammatory response, and an effective inhibitor would suppress… 
Review
1990
Review
1990
Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor; CD21).
The primary sequence of the A allotype of CR1 has been deduced from the cDNA sequence and includes a 41-residue signal peptide… 
Highly Cited
1989
Highly Cited
1989
Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele
Structural and quantitative polymorphisms have been described in human CR1. In the former, the S allotype is larger than the F… 
Review
1988
Review
1988
Structure, organization, and regulation of the complement genes.
cDNA and genomic clones are now available for nearly 30 glycoproteins which comprise the components, regulatory proteins, and… 
Highly Cited
1985
Highly Cited
1985
Family studies of erythrocyte complement receptor type 1 levels: reduced levels in patients with SLE are acquired, not inherited.
It has been claimed that patients with systemic lupus erythematosus (SLE) have an inherited deficiency of erythrocyte complement… 
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