Complement Receptor Type 1

Patients with systemic lupus erythematosus (SLE) have relative deficiencies of the C3b/C4b receptor (CR1, CD35) on erythrocytes… (More)

The complement system---particularly component C3---has been demonstrated to be a key link between innate and adaptive immunity… (More)

Human complement receptor type 1 (CR1) is a large, multifunctional glycoprotein which is a member of the regulators of complement… (More)

Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis. Complement activation leads… (More)

BACKGROUND Cancer patients treated with the anticancer drug, paclitaxel (Taxol) often experience mild to severe hypersensitivity… (More)

Two functionally distinct but homologous sites in complement receptor type 1 (CR1) (CD35) were further characterized by… (More)

Molecular definition of the cellular receptor for the collagen domain of C1q has been elusive. We now report that C1q binds… (More)

A new approach has been used to extend the T(1/2) of human soluble complement receptor type 1 (sCR1) in rats. The albumin-binding… (More)

We examined the role of C activation in ischemia reperfusion injury by inhibiting C activation in a rat model of mesenteric… (More)

The complement system is an important mediator of the acute inflammatory response, and an effective inhibitor would suppress… (More)