CR1 gene

Known as: C3BR, C4BR, CR1 
This gene is involved in the complement activation pathway.
National Institutes of Health

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CR1 wt Allele
Complement ActivationComplement Receptor Type 1Knops blood group system

Papers overview

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Review
2017
Review
2017
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
INTRODUCTION The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of… (More)
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Highly Cited
2011
Highly Cited
2011
CR1 is associated with amyloid plaque burden and age-related cognitive decline.
OBJECTIVE Recently, genome-wide association studies have identified 3 new susceptibility loci for Alzheimer's disease (AD), CLU… (More)
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Highly Cited
2010
Highly Cited
2010
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
OBJECTIVES To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD… (More)
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Highly Cited
2010
Highly Cited
2010
Replication of CLU, CR1, and PICALM associations with alzheimer disease.
OBJECTIVE To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease… (More)
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Highly Cited
2010
Highly Cited
2010
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on… (More)
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Highly Cited
2009
Highly Cited
2009
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's… (More)
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Highly Cited
1997
Highly Cited
1997
Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice.
Human complement receptors type 1 (hCR1;CD35) and type 2 (hCR2;CD21) are expressed on B lymphocytes at specific stages during… (More)
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Highly Cited
1990
Highly Cited
1990
The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1.
The murine Cr2 gene encodes at least two related proteins. The first of these is predicted to include 1408 amino acids from a… (More)
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Highly Cited
1988
Highly Cited
1988
Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis
Complementary DNA clones encoding the NH2-terminal region of human CR1 have been isolated and sequenced. The deduced complete… (More)
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Highly Cited
1982
Highly Cited
1982
Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes
The main finding of this paper is that CR1, the membrane receptor for C3b and C4b, together with C3b/C4b-inactivator (I… (More)
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