Colorectal Cancer

Known as: Colon/rectal cancer, Cancers, Colorectal, Cancer colo-rectal 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
010020019562016

Papers overview

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Highly Cited
2012
Highly Cited
2012
A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance… (More)
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Highly Cited
2010
Highly Cited
2010
Despite the presence of mutations in APC or β-catenin, which are believed to activate the Wnt signalling cascade constitutively… (More)
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Highly Cited
2007
Highly Cited
2007
Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant WNT pathway signaling is an early progression event in 90% of colorectal cancers. It occurs through mutations mainly of… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… (More)
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Highly Cited
1998
Highly Cited
1998
Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of… (More)
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Highly Cited
1997
Highly Cited
1997
It has long been considered that genetic instability is an integral component of human neoplasia1–3. In a small fraction of… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND/AIMS Several clinical, epidemiological, and animal studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs… (More)
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Highly Cited
1990
Highly Cited
1990
Allelic deletions involving chromosome 18q occur in more than 70 percent of colorectal cancers. Such deletions are thought to… (More)
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Highly Cited
1987
Highly Cited
1987
The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories… (More)
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