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Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression. Expand
Cell death: the significance of apoptosis.
It has proved feasible to categorize most if not all dying cells into one or the other of two discrete and distinctive patterns of morphological change, which have, generally, been found to occur under disparate but individually characteristic circumstances. Expand
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
  • A. Wyllie
  • Chemistry, Medicine
  • Nature
  • 10 April 1980
It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease. Expand
Induction of apoptosis in fibroblasts by c-myc protein
It is demonstrated that deregulated c-myc expression induces apoptosis in cells growth arrested by a variety of means and at various points in the cell cycle. Expand
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.
Changes in the senescent neutrophil that are associated with their recognition by macrophages are the subject of this investigation, and these processes may represent a mechanism for the removal of neutrophils during inflammation that also serves to limit the degree of tissue injury. Expand
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients
This study demonstrates that a combination of techniques can be used to genetically diagnose tumor susceptibility in the majority of HNPCC kindreds and lays the foundation for genetic testing of this relatively common disease. Expand
Thymocyte apoptosis induced by p53-dependent and independent pathways
The results show that p53 exerts a significant and dose-dependent effect in the initiation of apoptosis, but only when it is induced by agents that cause DNA-strand breakage. Expand
Apoptosis: mechanisms and roles in pathology.
This chapter discusses the mechanisms and roles of apoptosis in pathology, and the arrival of neutrophil polymorphs permits digestion and phagocytosis of the constituents of the necrotic cells, but brings with it the risk of further tissue damage. Expand
Apoptosis. The role of the endonuclease.
In apoptosis, selective activation of an endogenous endonuclease appears to be responsible not only for widespread chromatin cleavage but also for the major nuclear morphologic changes, including conservation of the nucleolin-rich fibrillar center. Expand
Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
The data confirm that the condensed chromatin which characterizes apoptosis morphologically consists of endogenously digested chromatin fragments, and provide support for the view that at least some cells enter apoptosis by a process dependent upon macromolecular synthesis. Expand