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Cofilin 1

Known as: N-Cofilin, Non Muscle Cofilin, Cofilin-1 
Cofilin 1 is a member of the cofilin family of proteins that is expressed in non-muscle CELLS. It has ACTIN depolymerization activity that is… 
National Institutes of Health

Related topics

Related topics

21 relations
Actin-Binding ProteinAxon GuidanceCCR3 Signaling PathwayCell Nucleus

Broader (1)

CFL1 gene

Narrower (2)

Cfl1 protein, mouseCfl1 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Cofilin 1 promotes bladder cancer and is regulated by TCF7L2
Earlier reports demonstrated that Cofilin expression is increased in bladder cancer samples, though its function remains unknown… 
2014
2014
Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid
The pathogenesis of gastric cancer is characterized by excessive proliferation, abnormal differentiation, and reduced apoptosis… 
2014
2014
Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
2012
2012
Identification of phosphorylated serine-15 and -82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics.
Highly Cited
2011
Highly Cited
2011
Comparative Proteomic Approach Identifies Pkm2 and Cofilin-1 as Potential Diagnostic, Prognostic and Therapeutic Targets for Pulmonary Adenocarcinoma
Lung cancer is the leading cause of cancer-related death in the world. Non-small cell lung carcinomas (Non-SCLC) account for… 
2009
2009
A proteomic study reveals unspecific apoptosis induction and reduction of glycolytic enzymes by the phosphorothioate antisense oligonucleotide oblimersen in human melanoma cells.
2009
2009
Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering.
Cofilin is a key player in actin dynamics during cell migration. Its activity is regulated by (de)phosphorylation, pH, and… 
2004
2004
Non-Muscle Cofilin Is a Component of Tubulobulbar Complexes in the Testis1
Abstract Tubulobulbar complexes are finger-like structures that form at the interface between maturing spermatids and Sertoli… 
Highly Cited
1998
Highly Cited
1998
Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode.
An understanding of the actin-depolymerizing function attributed to members of the ADF/cofilin/destrin superfamily requires a… 
Highly Cited
1995
Highly Cited
1995
Effects of cofilin on actin filamentous structures in cultured muscle cells. Intracellular regulation of cofilin action.
The previous investigation (Abe et al. (1989) J. Biochem. 106, 696-702) suggested that cofilin is deeply involved in the… 
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