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Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models
The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB) in vitro. Transport studies with celecoxib, diclofenac,… Expand
Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells.
Immortalized porcine brain microvessel endothelial cells (PBMEC/C1-2) were used to develop a model for measurement of blood-brain barrier permeation of central nervous system active drugs. Previous… Expand
A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2.
- W. Neuhaus, R. Lauer, S. Oelzant, U. P. Fringeli, G. Ecker, C. Noe
- Chemistry, Medicine
- Journal of biotechnology
- 20 August 2006
A flow based hollow-fiber in vitro model of the blood-brain barrier (BBB) was established. The immortalised porcine brain microvascular endothelial cell line PBMEC/C1-2 was cultured in a pulsatile… Expand
Structural modifications of antisense oligonucleotides.
Antisense oligonucleotides are efficient tools for the inhibition of gene expression in a sequence specific way. Natural oligonucleotides are decomposed rapidly in biological systems, which strongly… Expand
Effects of NMDA receptor modulators on a blood–brain barrier in vitro model
- W. Neuhaus, Michael Freidl, Phillip Szkokan, M. Berger, C. Noe
- Biology, Medicine
- Brain Research
- 7 June 2011
Changes of the functionality of the blood-brain barrier (BBB) have been reported in the context of several brain related diseases such as multiple sclerosis, epilepsy, Alzheimer's disease and stroke.… Expand
Two‐dimensional electrophoresis of recombinant human erythropoietin: A future method for the European Pharmacopoeia?
Quality assurance of recombinant protein drugs concerning identity and purity represents a difficult task, in particular, when post‐translational modifications lead to a heterogeneous mixture of… Expand
Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier.
The roots and rhizome of Valeriana officinalis L . s. l. are therapeutically used for their sedative and sleep-enhancing effects. Some of the active compounds found in commonly used extracts are the… Expand
Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs.
In the course of our validation program testing blood-brain barrier (BBB) in vitro models for their usability as tools in drug discovery it was evaluated whether an established Transwell model based… Expand
Capillary zone electrophoresis of aldose enantiomers: separation after derivatization with S-(−)-1-phenylethylamine☆
A method for the analysis of monosaccharide enantiomers of the aldose-type is described. Aminoalditols resulting from derivatization with S-(−)-1-phenylethylamine were subjected to capillary… Expand
In silico prediction models for blood-brain barrier permeation.
The ability to permeate across the blood brain barrier (BBB) is essential for drugs acting on the central nervous system (CNS). Thus, for speeding up the drug discovery process in the CNS-area, it is… Expand