C. Noe

Publications282
h-index27
Citations2,295
Highly Influential Citations33
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Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models
The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB) in vitro. Transport studies with celecoxib, diclofenac,… Expand
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Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells.
Immortalized porcine brain microvessel endothelial cells (PBMEC/C1-2) were used to develop a model for measurement of blood-brain barrier permeation of central nervous system active drugs. Previous… Expand
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A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2.
A flow based hollow-fiber in vitro model of the blood-brain barrier (BBB) was established. The immortalised porcine brain microvascular endothelial cell line PBMEC/C1-2 was cultured in a pulsatile… Expand
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Structural modifications of antisense oligonucleotides.
Antisense oligonucleotides are efficient tools for the inhibition of gene expression in a sequence specific way. Natural oligonucleotides are decomposed rapidly in biological systems, which strongly… Expand
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Effects of NMDA receptor modulators on a blood–brain barrier in vitro model
Changes of the functionality of the blood-brain barrier (BBB) have been reported in the context of several brain related diseases such as multiple sclerosis, epilepsy, Alzheimer's disease and stroke.… Expand
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Two‐dimensional electrophoresis of recombinant human erythropoietin: A future method for the European Pharmacopoeia?
Quality assurance of recombinant protein drugs concerning identity and purity represents a difficult task, in particular, when post‐translational modifications lead to a heterogeneous mixture of… Expand
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Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier.
The roots and rhizome of Valeriana officinalis L . s. l. are therapeutically used for their sedative and sleep-enhancing effects. Some of the active compounds found in commonly used extracts are the… Expand
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Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs.
In the course of our validation program testing blood-brain barrier (BBB) in vitro models for their usability as tools in drug discovery it was evaluated whether an established Transwell model based… Expand
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Capillary zone electrophoresis of aldose enantiomers: separation after derivatization with S-(−)-1-phenylethylamine☆
A method for the analysis of monosaccharide enantiomers of the aldose-type is described. Aminoalditols resulting from derivatization with S-(−)-1-phenylethylamine were subjected to capillary… Expand
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In silico prediction models for blood-brain barrier permeation.
The ability to permeate across the blood brain barrier (BBB) is essential for drugs acting on the central nervous system (CNS). Thus, for speeding up the drug discovery process in the CNS-area, it is… Expand
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