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Codon, Nonsense

Known as: Codon, Premature Stop, Codon, Premature Termination, Premature Stop Codons 
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature… 
National Institutes of Health

Related topics

Related topics

15 relations
Amber Nonsense MutationCodon, UnassignedIn BloodNonsense mutation

Narrower (2)

Ochre Nonsense CodonOpal Nonsense Codon

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Ataluren treatment of patients with nonsense mutation dystrophinopathy
Introduction: Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was… 
Highly Cited
2011
Highly Cited
2011
Modifying the genetic code: Converting nonsense codons into sense codons by targeted pseudouridylation
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon. Here… 
Review
2004
Review
2004
Nonsense-mediated decay approaches the clinic
Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination codons and thus helps limit the synthesis of… 
Highly Cited
2004
Highly Cited
2004
A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay
Nonsense-mediated messenger RNA decay (NMD) is triggered by premature translation termination, but the features distinguishing… 
Highly Cited
2004
Highly Cited
2004
A Putative Ca2+ and Calmodulin-Dependent Protein Kinase Required for Bacterial and Fungal Symbioses
Legumes can enter into symbiotic relationships with both nitrogen-fixing bacteria (rhizobia) and mycorrhizal fungi. Nodulation by… 
Highly Cited
2000
Highly Cited
2000
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
We describe here eleven different mutations in SPINK5, encoding the serine protease inhibitor LEKTI, in 13 families with… 
Highly Cited
1998
Highly Cited
1998
Binary specification of nonsense codons by splicing and cytoplasmic translation
Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders… 
Highly Cited
1994
Highly Cited
1994
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.
A genetic polymorphism in the metabolism of the anticonvulsant drug (S)-mephenytoin has been well documented in humans. There are… 
Highly Cited
1991
Highly Cited
1991
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.
mRNA decay rates often increase when translation is terminated prematurely due to a frameshift or nonsense mutation. We have… 
Highly Cited
1979
Highly Cited
1979
Interference of nonsense mutations with eukaryotic messenger RNA stability.
The fine structure map of the yeast URA 3 gene was established by meiotic recombination, and amber nonsense mutations were… 
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