Codon, Nonsense

Known as: Codon, Premature Stop, Codon, Premature Termination, Premature Stop Codons 
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation… (More)
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Review
2008
Review
2008
Alternative splicing (AS) strongly affects gene expression by generating protein isoform diversity. However, up to one-third of… (More)
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Highly Cited
2007
Highly Cited
2007
Nonsense mutations promote premature translational termination and cause anywhere from 5–70% of the individual cases of most… (More)
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Highly Cited
2007
Highly Cited
2007
Many alternative splicing events create RNAs with premature stop codons, suggesting that alternative splicing coupled with… (More)
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Highly Cited
2004
Highly Cited
2004
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD… (More)
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Review
2004
Review
2004
Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination codons and thus helps limit the synthesis of… (More)
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Highly Cited
2003
Highly Cited
2003
To better understand the role of alternative splicing, we conducted a large-scale analysis of reliable alternative isoforms of… (More)
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Highly Cited
2000
Highly Cited
2000
Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are… (More)
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Highly Cited
1998
Highly Cited
1998
Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders… (More)
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Review
1995
Review
1995
It appears that no organism is immune to the effects of nonsense codons on mRNA abundance. The study of how nonsense codons alter… (More)
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