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Codon, Nonsense

Known as: Codon, Premature Stop, Codon, Premature Termination, Premature Stop Codons 
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Nat. Genet. 41, 991–995 (2009); published online 2 August; corrected online 23 August 2009 In the version of this article… Expand
Review
2007
Review
2007
Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination… Expand
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Highly Cited
2007
Highly Cited
2007
Nonsense mutations promote premature translational termination and cause anywhere from 5–70% of the individual cases of most… Expand
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Highly Cited
2004
Highly Cited
2004
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD… Expand
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Review
2004
Review
2004
Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination codons and thus helps limit the synthesis of… Expand
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Highly Cited
2002
Highly Cited
2002
To better understand the role of alternative splicing, we conducted a large-scale analysis of reliable alternative isoforms of… Expand
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Highly Cited
2000
Highly Cited
2000
Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are… Expand
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Highly Cited
1998
Highly Cited
1998
The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events… Expand
Review
1995
Review
1995
It appears that no organism is immune to the effects of nonsense codons on mRNA abundance. The study of how nonsense codons alter… Expand
Highly Cited
1994
Highly Cited
1994
BACKGROUND AND METHODS Mutations in the estrogen-receptor gene have been thought to be lethal. A 28-year-old man whose estrogen… Expand