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Nat. Genet. 41, 991–995 (2009); published online 2 August; corrected online 23 August 2009 In the version of this article… Expand Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination… Expand Nonsense mutations promote premature translational termination and cause anywhere from 5–70% of the individual cases of most… Expand Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD… Expand Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination codons and thus helps limit the synthesis of… Expand To better understand the role of alternative splicing, we conducted a large-scale analysis of reliable alternative isoforms of… Expand Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are… Expand The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events… Expand It appears that no organism is immune to the effects of nonsense codons on mRNA abundance. The study of how nonsense codons alter… Expand BACKGROUND AND METHODS
Mutations in the estrogen-receptor gene have been thought to be lethal. A 28-year-old man whose estrogen… Expand