D. Prockop

Publications738
h-index130
Citations79,184
Highly Influential Citations1,923
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Adult rat and human bone marrow stromal cells differentiate into neurons
TLDR
Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
TLDR
Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.
TLDR
A protocol that provides rapidly expanding MSCs from 5 strains of inbred mice with differences in their media requirements for optimal growth, rates of propagation, and presence of the surface epitopes CD34, stem cell antigen-1 (Sca-1), and vascular cell adhesion molecule 1 (VCAM-1).
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
TLDR
Marrow stromal cells constitute an easily accessible, easily expandable source of cells that may prove useful in the establishment of spinal cord repair protocols and possibly effects on functional outcome in animals rendered paraplegic.
Collagens: molecular biology, diseases, and potentials for therapy.
TLDR
The collagen superfamily of proteins now contains at least 19 proteins formally defined as collagens and an additional ten proteins that have collagen-like domains, and a number of experiments suggest it may be possible to inhibit collagen synthesis with oligo-nucleotides or antisense genes.
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties
TLDR
The data suggest that spheroid hMSCs may be more effective than h MSCs from adherent cultures in therapies for diseases characterized by sterile tissue injury and unresolved inflammation and for some cancers that are sensitive to antiinflammatory agents.
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
TLDR
Critically evaluate the literature describing the plasticity of MSCs and offer insight into how the molecular and functional heterogeneity of this cell population, which reflects the complexity of marrow stroma as an organ system, may confound interpretation of their transdifferentiation potential.
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells
TLDR
It is found that early colonies of marrow stromal cells contain a third kind of cell: very small round cells that rapidly self-renew and have a greater potential for multipotential differentiation than samples enriched for the large cells.
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans
TLDR
The data on genotype–phenotype relationships indicate that the two collagen chains play very different roles in matrix integrity and that phenotype depends on intracellular and extracellular events.
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