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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Large-scale analysis of the human and mouse transcriptomes
This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is…
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
- W. R. Wikoff, A. Anfora, G. Siuzdak
- Biology, ChemistryProceedings of the National Academy of Sciences
- 10 March 2009
A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost.
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR) and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.
A chemical switch for inhibitor-sensitive alleles of any protein kinase
A chemical genetic strategy for sensitizing protein kinases to cell-permeable molecules that do not inhibit wild-type kinases is described, allowing for rapid functional characterization of members of this important gene family.
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT
An ncRNA repressor of the nuclear factor of activated T cells (NFAT), which interacts with multiple proteins including members of the importin-beta superfamily and likely functions as a specific regulator of NFAT nuclear trafficking is identified.
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- Jun Liu, Shifeng Pan, Jennifer L. Harris
- BiologyProceedings of the National Academy of Sciences
- 25 November 2013
LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30).
Adding new chemistries to the genetic code.
The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids to the genetic codes of Escherichia coli, yeast, and mammalian cells, which provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function.
Molecular classification of human carcinomas by use of gene expression signatures.
This study demonstrates the feasibility of predicting the tissue origin of a carcinoma in the context of multiple cancer classes by accurately and confidently predicting the anatomical site of tumor origin for 90% of 175 carcinomas, including 9 of 12 metastatic lesions.