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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling toExpand
Large-scale analysis of the human and mouse transcriptomes
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experimentsExpand
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and isExpand
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Although it has long been recognized that the enteric community of bacteria that inhabit the human distal intestinal track broadly impacts human health, the biochemical details that underlie theseExpand
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Stem Cell Expansion The ability to expand hematopoietic stem cells (HSCs) during ex-vivo culture has been an important goal for over 20 years. Using a high-throughput chemical screen, Boitano et al.Expand
A chemical switch for inhibitor-sensitive alleles of any protein kinase
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts toExpand
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT
Noncoding RNA molecules (ncRNAs) have been implicated in numerous biological processes including transcriptional regulation and the modulation of protein function. Yet, in spite of the apparentExpand
Expanding the Genetic Code of Escherichia coli
A unique transfer RNA (tRNA)/aminoacyl-tRNA synthetase pair has been generated that expands the number of genetically encoded amino acids in Escherichia coli. When introduced into E. coli, this pairExpand
Molecular classification of human carcinomas by use of gene expression signatures.
Classification of human tumors according to their primary anatomical site of origin is fundamental for the optimal treatment of patients with cancer. Here we describe the use of large-scale RNAExpand
Effects of environmental enrichment on gene expression in the brain.
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To betterExpand