Clonal Evolution

Known as: Evolution, Clonal 
The process by which a normal cell accumulates genetic changes that allow it to become a tumor-causing cell and furthers its development to more… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2018
05010015019682018

Papers overview

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Highly Cited
2016
Highly Cited
2016
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial… (More)
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Highly Cited
2015
Highly Cited
2015
Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and clonal evolution. The molecular profile… (More)
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Highly Cited
2014
Highly Cited
2014
BRAF inhibitors elicit rapid antitumor responses in the majority of patients with BRAF(V600)-mutant melanoma, but acquired drug… (More)
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Highly Cited
2014
Highly Cited
2014
Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an… (More)
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Highly Cited
2012
Highly Cited
2012
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal… (More)
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Highly Cited
2012
Highly Cited
2012
Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a… (More)
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Highly Cited
2012
Highly Cited
2012
Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other… (More)
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Highly Cited
1997
Highly Cited
1997
To understand the genetic basis and clonal evolution underlying metastatic progression of human breast cancer in vivo, we… (More)
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Highly Cited
1992
Highly Cited
1992
The potential role antigens play in growth stimulation or in clonal selection of follicular lymphomas is unknown. To study this… (More)
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Highly Cited
1976
Highly Cited
1976
It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic… (More)
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