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Clonal Evolution

Known as: Evolution, Clonal 
The process by which a normal cell accumulates genetic changes that allow it to become a tumor-causing cell and furthers its development to more… 
National Institutes of Health

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Clonal Selection, Antigen-MediatedPathologic ProcessesTumor Progressionaspects of radiation effects

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Somatic Evolution

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Eltrombopag for Refractory Severe Aplastic Anemia: Dosing Regimens, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling
Eltrombopag (EPAG) received FDA approval for treatment of refractory severe aplastic anemia (rSAA) in 2014, based on our phase I… 
2003
2003
Detection of T-cell Receptor y Chain V Gene Rearrangements Using the Polymerase Chain Reaction : Application to the Study of Clonal Disease Cells in Acute Lymphoblastic Leukemia
This report describes the development and characterization of a method for the amplification of rearranged V-J segments of the… 
Review
1997
Review
1997
Chromosome 8 tetrasomies and pentasomies--a clonal abnormality closely associated with acute monocytic leukaemia.
We report four cases of polysomy 8 (one tetrasomy and three pentasomies) observed in acute monocytic leukemia (FAB M4 and M5… 
1990
1990
Use of Lymphoid Progenitor Cell Assays for a More Detailed Analysis of the Cytogenetic Changes Occurring During Clonal Evolution in Acute Lymphoblastic Leukemia.
Karyotypic and immunophenotypic changes during clonal evolution were studied in 5 B-lineage and 5 T-lineage acute lymphoblastic… 
Highly Cited
1987
Highly Cited
1987
Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region.
A 2.8-kilobase major breakpoint region on chromosome segment 18q21 is the site of most t(14;18) translocations typical of human… 
1986
1986
Borderline malignant serous tumors of the ovary maintained on extracellular matrix: evidence for clonal evolution and invasive potential.
Four cases of advanced stage (II or III) and one case of early stage (IC) borderline malignant serous cystadenocarcinomas of the… 
1982
1982
Clonal evolution demonstrated by flow cytometric DNA analysis of a human colonic carcinoma grown in nude mice.
A spontaneous change in DNA content of a human colonic carcinoma grown in nude mice was observed fortuitously. The tumor… 
1979
1979
Clonal evolution of marker chromosomes in a case of myelofibrosis with myeloid metaplasia and myeloblastic transformation.
The diverse spectrum of acquired chromosome abnormalities in a female patient with myelofibrosis and myeloid metaplasia is… 
1977
1977
Cytogenetic evidence of clonal evolution in 5q- anemia.
The clinical homogeneity of myeloproliferative syndromes associated with a 5 q- marker can be contested, but nevertheless finds… 
1968
1968
A chromosome study of seven near-diploid carcinomas of the corpus uteri.
ImagesFig. 4Fig. 5Fig. 6Fig. 8Fig. 9Fig. 10Fig. 1Fig. 2Fig. 7Fig. 3 
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