Skip to search formSkip to main contentSkip to account menu

Clonal Selection, Antigen-Mediated

Known as: Antigen-Mediated Clonal Selection, Selection, Antigen-Mediated Clonal, Antigen Mediated Clonal Selection 
LYMPHOCYTE ACTIVATION by a specific ANTIGEN thus triggering clonal expansion of LYMPHOCYTES already capable of mounting an immune response to the… 
National Institutes of Health

Related topics

Related topics

4 relations
Antibody FormationClonal Evolutionaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection1
The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we… 
Highly Cited
2003
Highly Cited
2003
Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells
Activation of naive CD8 T cells to undergo clonal expansion and develop effector function requires three signals: (a) Ag, (b… 
Highly Cited
2003
Highly Cited
2003
Single-Cell Repertoire Analysis Demonstrates that Clonal Expansion Is a Prominent Feature of the B Cell Response in Multiple Sclerosis Cerebrospinal Fluid 1
Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid (CSF) of patients with multiple sclerosis… 
Highly Cited
2002
Highly Cited
2002
CD28 Costimulation Mediates Down-Regulation of p27kip1 and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells1
CD28 provides a costimulatory signal that cooperates with the TCR/CD3 complex to induce T cell activation, cytokine production… 
Highly Cited
1999
Highly Cited
1999
Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.
The adoptive transfer of TCR-transgenic T cells into syngeneic recipients allows characterization of individual T cells during in… 
Highly Cited
1998
Highly Cited
1998
A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism
The adoptive transfer of naive CD4+ T cell receptor (TCR) transgenic T cells was used to investigate the mechanisms by which the… 
Highly Cited
1995
Highly Cited
1995
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
The importance of CD28 costimulation to a primary T cell response in vivo was assessed in an adoptive transfer system where a… 
Highly Cited
1992
Highly Cited
1992
Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.
Clonal expansion of naive CD4 T cells is a necessary step in most adaptive immune responses. Two distinct signals are required… 
Highly Cited
1990
Highly Cited
1990
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor
SIGNALLING by membrane immunoglobulin, the B-lymphocyte antigen receptor, regulates B-cell maturation and activation… 
Highly Cited
1979
Highly Cited
1979
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression
The nature of Ia antigens which appear on human T cells after activation and the stimuli required for their expression was… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)