Clodronate Disodium

Known as: sodium clodronate, Clodronate Sodium, disodium clodronate 
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Macrophages are abundant in the lower respiratory tract. They play a central role in the innate response to infection but may… (More)
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Highly Cited
2006
Highly Cited
2006
Tumour-associated macrophages, TAMs, play a pivotal role in tumour growth and metastasis by promoting tumour angiogenesis… (More)
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Highly Cited
2006
Highly Cited
2006
Introduction Experimental and clinical data show that the oral bisphosphonate clodronate (Bonefos®) can inhibit tumorinduced… (More)
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Highly Cited
2006
Highly Cited
2006
The study evaluates the influence of monocytes/macrophages in the mechanisms of skeletal muscle injury using a mouse model and… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Although neutrophils and T cells are important in mediating renal injury following ischaemia/reperfusion, the role of… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by… (More)
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Highly Cited
2002
Highly Cited
2002
Hepatic injury induced by various toxic agents, including acetaminophen (APAP), has been attributed, in part, to the production… (More)
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Highly Cited
2000
Highly Cited
2000
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Bisphosphonates are effective against the increased bone resorption caused by certain diseases because they inhibit… (More)
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Highly Cited
1997
Highly Cited
1997
Clodronate, alendronate, and other bisphosphonates are widely used in the treatment of bone diseases characterized by excessive… (More)
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