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Clodronate Disodium

Known as: sodium clodronate, Clodronate Sodium, disodium clodronate 
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits… 
National Institutes of Health

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BonefosClasteonDifosfonal
CLODRONATE DISODIUM 60 mg in 1 mL INTRAMUSCULAR INJECTION, SOLUTION [OSPHOS]Clodronic Acidclodronate/mitoxantrone/prednisone

Broader (1)

Clodronate

Papers overview

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Highly Cited
2011
Highly Cited
2011
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high‐fat diet
We aimed to evaluate activation of macrophages in insulin‐sensitive tissues (liver, adipose tissue, and muscles) under high‐fat… 
Highly Cited
2009
Highly Cited
2009
Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials
Highly Cited
2007
Highly Cited
2007
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Clinical trials have proven oncolytic virotherapy to be safe but not effective. We have shown that oncolytic viruses (OV… 
Highly Cited
2007
Highly Cited
2007
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia
Highly Cited
2006
Highly Cited
2006
Macrophages contribute to the initiation of ischaemic acute renal failure in rats.
BACKGROUND Although neutrophils and T cells are important in mediating renal injury following ischaemia/reperfusion, the role of… 
Highly Cited
2002
Highly Cited
2002
Macrophage Depletion by Clodronate-Containing Liposomes Reduces Neointimal Formation After Balloon Injury in Rats and Rabbits
Background—Inflammation is critical to vascular repair after mechanical injury. Excessive inflammation enhances neointimal… 
Highly Cited
2001
Highly Cited
2001
Meningeal and Perivascular Macrophages of the Central Nervous System Play a Protective Role During Bacterial Meningitis
Meningeal (MM) and perivascular macrophages (PVM) constitute major populations of resident macrophages in the CNS that can be… 
Highly Cited
2000
Highly Cited
2000
Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… 
Highly Cited
1996
Highly Cited
1996
Kupffer cell depletion by liposome‐delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid
Macrophages such as Kupffer cells in the liver are multifunctional cells. They are involved in host defense mechanisms and have a… 
Highly Cited
1980
Highly Cited
1980
EFFECT OF DICHLOROMETHYLENE DIPHOSPHONATE IN PAGET'S DISEASE OF BONE AND IN HYPERCALCÆMIA DUE TO PRIMARY HYPERPARATHYROIDISM OR MALIGNANT DISEASE
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