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Clodronate Disodium

Known as: sodium clodronate, Clodronate Sodium, disodium clodronate 
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits… 
National Institutes of Health

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BonefosClasteonDifosfonal
CLODRONATE DISODIUM 60 mg in 1 mL INTRAMUSCULAR INJECTION, SOLUTION [OSPHOS]Clodronic Acidclodronate/mitoxantrone/prednisone

Broader (1)

Clodronate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.
2011
2011
Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells.
Bisphoshonates are used clinically to treat disorders of calcium metabolism, hypercalcemia and osteoporosis, and malignant bone… 
Highly Cited
2006
Highly Cited
2006
Reduction of Renal Fibrosis as a Result of Liposome Encapsulated Clodronate Induced Macrophage Depletion after Unilateral Ureteral Obstruction in Rats
Background/Aim: Macrophages have been thought to play a role in renal tubulointerstitial fibrosis; recent reports have… 
2005
2005
Macrophage-derived interleukin-18 in experimental renal allograft rejection.
BACKGROUND Interleukin 18 (IL-18) is primarily a macrophage-derived, pro-inflammatory cytokine. As macrophages can act as… 
Highly Cited
2003
Highly Cited
2003
Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry…
1999
1999
Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin‐2 in a mouse model
The haemolytic uraemic syndrome (HUS) is a clinical syndrome consisting of haemolytic anaemia, thrombocytopenia, and acute renal… 
1999
1999
Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment.
PURPOSE Corneal allograft rejection in rats can be prevented by subconjunctival injections of liposomes containing… 
Highly Cited
1997
Highly Cited
1997
Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo
The consequences of macrophage depletion achieved by intravenous infusion of liposome-encapsulated clodronate (dichlormethylene… 
1989
1989
Pharmacokinetics of disodium clodronate after daily intravenous infusions during five consecutive days.
The pharmacokinetics of disodium clodronate was studied in six patients, three females and two males with Paget's disease and one… 
1983
1983
Drug treatment of primary hyperparathyroidism: use of clodronate disodium.
Clodronate disodium (dichloromethylene diphosphonate), a specific inhibitor of bone resorption, was given by mouth (1.0-3.2 g… 
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