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Clodronic Acid

Known as: (Dichloro-phosphono-methyl)-phosphonic acid, (Dichloromethylene)bisphosphonic Acid, Acid, Dichloromethanediphosphonic 
A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Bone Density Conservation AgentsClodronate

Narrower (3)

Bonefosdifluoromethylene diphosphonatedifluoromethylenesulfonic acid
CLODRONATE DISODIUM 60 mg in 1 mL INTRAMUSCULAR INJECTION, SOLUTION [OSPHOS]Clodronate DisodiumIn Bloodagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Structural and magnetic resolution of a two-step full spin-crossover transition in a dinuclear iron(II) pyridyl-bridged compound.
A dinuclear iron(II) complex containing the new pyridyl bridging ligand, 2,5-di(2',2''-dipyridylamino)pyridine (ddpp) has been… 
Highly Cited
2000
Highly Cited
2000
Pig islet xenograft rejection is markedly delayed in macrophage‐depleted mice: a study in streptozotocin diabetic animals
Abstract: The present study aimed to evaluate the effect of depletion of macrophages and/or natural killer (NK) cells on islet… 
Highly Cited
1999
Highly Cited
1999
Macrophage depletion alters vein graft intimal hyperplasia.
Highly Cited
1997
Highly Cited
1997
Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo
The consequences of macrophage depletion achieved by intravenous infusion of liposome-encapsulated clodronate (dichlormethylene… 
Highly Cited
1994
Highly Cited
1994
Prevention of corneal allograft rejection in rats treated with subconjunctival injections of liposomes containing dichloromethylene diphosphonate.
PURPOSE The drug dichloromethylene diphosphonate (CL2MDP) encapsulated in liposomes depletes macrophages but not other… 
Highly Cited
1994
Highly Cited
1994
Isolation and characterization of the Methylophilus sp. strain DM11 gene encoding dichloromethane dehalogenase/glutathione S-transferase
The restricted facultative methylotroph Methylophilus sp. strain DM11 utilizes dichloromethane as the sole carbon and energy… 
Highly Cited
1993
Highly Cited
1993
Liposome-mediated macrophage depletion: an experimental approach to study the role of testicular macrophages in the rat.
Liposome-entrapped dichloromethylene diphosphonate was injected locally into the right testes of adult rats. This treatment… 
Highly Cited
1989
Highly Cited
1989
The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin…
The primary antibody response to intravenously administered and liposome-associated human serum albumin (HSA) was studied in mice… 
Highly Cited
1986
Highly Cited
1986
Influence of carriers on the development and localization of anti‐2,4,6‐trinitrophenyl (TNP) antibody‐forming cells in the murine spleen: II. Suppressed antibody response to TNP‐Ficoll after…
The macrophages in the marginal zones in mice spleens were eliminated by i.v. injection of dichloromethylene diphosphonate… 
Highly Cited
1967
Highly Cited
1967
Effects of some inhibitors of protein synthesis on the binding of aminoacyl tRNA to ribosomal subunits.
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