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Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search
TLDR
The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1, and an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. Expand
Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial
TLDR
In patients with locally advanced or high-risk local prostate cancer, addition of local radiotherapy to endocrine treatment halved the 10-year prostate-cancer-specific mortality, and substantially decreased overall mortality with fully acceptable risk of side-effects compared with endocrine Treatment alone. Expand
Urinary Incontinence and Erectile Dysfunction After Robotic Versus Open Radical Prostatectomy: A Prospective, Controlled, Nonrandomised Trial.
TLDR
In a Swedish setting, RALP for prostate cancer was modestly beneficial in preserving erectile function compared with RRP, without a statistically significant difference regarding urinary incontinence or surgical margins. Expand
Prostate cancer
TLDR
The disparity between reported incidence and mortality rates leads to the probable conclusion that only a small proportion of diagnosed low-risk prostate cancers will progress to life-threatening disease during the lifetime of the patient. Expand
Risk perception, screening practice and interest in genetic testing among unaffected men in families with hereditary prostate cancer.
TLDR
It is concluded that hereditary susceptibility to prostate cancer has significant psychological consequences although it rarely causes psychiatric morbidity, underlines the importance of giving thorough, repeated information to men at high risk of prostate cancer. Expand
Segregation analysis of prostate cancer in Sweden: support for dominant inheritance.
TLDR
This study confirms the result from one earlier published segregation analysis and provides the context for interpreting the recently published linkage of hereditary prostate cancer families to chromosome 1q 24-25 (HPC1). Expand
N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer.
TLDR
The results indicate that androgen deprivation induces N-cadherin in prostate tumors and was increased in castration-resistant tumors in patients with established metastases. Expand
Evidence for a Prostate Cancer Susceptibility Locus on the X Chromosome
TLDR
This work presents a meta-modelling framework for estimating the number of neurons in the response of the autonomic nervous system and describes its properties in mice. Expand
Evidence for a prostate cancer susceptibility locus on the X chromosome.
TLDR
Evidence for genetic locus heterogeneity was observed and genetic mapping of the locus represents an important initial step in the identification of an X-linked gene implicated in the aetiology of HPC. Expand
Combined orchiectomy and external radiotherapy versus radiotherapy alone for nonmetastatic prostate cancer with or without pelvic lymph node involvement: a prospective randomized study.
TLDR
The results strongly suggest that early androgen deprivation is better than deferred endocrine treatment for patients with prostate cancer and pelvic lymph node involvement and overall survival rates are significantly better after combined androgen ablation and radiotherapy than after radiotherapy alone. Expand
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